학술논문
First Report of bla VIM-4 - and mcr-9 -Coharboring Enterobacter Species Isolated from a Pediatric Patient.
Document Type
Academic Journal
Author
Chavda KD; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.; Westblade LF; Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA.; Satlin MJ; Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA.; Hemmert AC; BioFire Diagnostics, LLC, Salt Lake City, Utah, USA.; Castanheira M; JMI Laboratories, North Liberty, Iowa, USA.; Jenkins SG; Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA.; Chen L; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.; Kreiswirth BN; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA Barry.Kreiswirth@hmh-cdi.org.
Source
Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101674533 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-5042 (Electronic) Linking ISSN: 23795042 NLM ISO Abbreviation: mSphere Subsets: MEDLINE
Subject
Language
English
Abstract
An Enterobacter hormaechei isolate harboring bla VIM-4 and mcr-9 was recovered from a pediatric patient in a U.S. hospital. The bla VIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The mcr-9 gene is located between two insertion elements, IS 903 and IS 1 , but lacks the downstream regulatory genes ( qseC and qseB ) found in other isolates that harbor mcr-9 IMPORTANCE We describe the complete genome assembly and sequence of a clinical Enterobacter isolate harboring both bla VIM-4 and mcr-9 recovered from a pediatric patient in the United States with a history of travel to Egypt. Moreover, to the best of our knowledge, this is the first report of an Enterobacter isolate harboring both bla VIM-4 and mcr-9 from the United States. The bla VIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The mcr-9 gene is located between two insertion elements, IS 903 and IS 1 , but lacks the downstream regulatory genes ( qseC and qseB ) found in other isolates that harbor mcr-9 .
(Copyright © 2019 Chavda et al.)
(Copyright © 2019 Chavda et al.)