학술논문
Human Campylobacter spp. infections in Italy.
Document Type
Academic Journal
Author
Zerbato V; Infectious Diseases Unit, Trieste University Hospital (ASUGI), Trieste, Italy. verena.zerbato@gmail.com.; Di Bella S; Clinical Department of Medical, Surgical and Health Sciences, Trieste University, Trieste, Italy.; Pol R; Infectious Diseases Unit, Trieste University Hospital (ASUGI), Trieste, Italy.; Luzzati R; Clinical Department of Medical, Surgical and Health Sciences, Trieste University, Trieste, Italy.; Sanson G; Clinical Department of Medical, Surgical and Health Sciences, Trieste University, Trieste, Italy.; Ambretti S; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.; Andreoni S; Laboratory of Microbiology and Virology, Azienda Ospedaliero Universitaria Maggiore Della Carità, Corso Mazzini 18, Novara, Italy.; Aschbacher R; Laboratorio Aziendale Di Microbiologia E Virologia, Comprensorio Sanitario Di Bolzano, Azienda Sanitaria Dell'Alto Adige, Bolzano, Italy.; Bernardo M; Microbiology Unit, AORN Ospedali Dei Colli-Monaldi Hospital, Naples, Italy.; Bielli A; Clinical Microbiology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.; Brigante G; Clinical Pathology Laboratory, ASST Valle Olona, Busto Arsizio, Italy.; Busetti M; Microbiology Unit, Trieste University Hospital (ASUGI), Trieste, Italy.; Camarlinghi G; Microbiology Analysis Unit, San Donato Hospital, USL Toscana Sud Est, Arezzo, Italy.; Carcione D; Clinical Pathology Laboratory, ASST Valle Olona, Busto Arsizio, Italy.; Carducci A; Clinical Pathology Laboratory, ASST Valle Olona, Busto Arsizio, Italy.; Clementi N; Laboratory of Microbiology and Virology at Vita-Salute San Raffaele University, Milan, Italy.; Laboratory of Medical Microbiology and Virology, IRCCS San Raffaele Hospital, Milan, Italy.; Carretto E; Clinical Microbiology Laboratory, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.; Chilleri C; Microbiology and Virology Unit, Careggi University Hospital, Florence, Italy.; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Codda G; Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.; Consonni A; Clinical Microbiology and Virology Unit, 'A. Manzoni' Hospital, Lecco, Italy.; Costantino V; Microbiology Unit, Trieste University Hospital (ASUGI), Trieste, Italy.; Cortazzo V; Dipartimento Di Scienze Biotecnologiche Di Base, Cliniche Intensivologiche E Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.; Microbiology and Diagnostic Immunology Unit, Department of Diagnostic and Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Di Santolo M; Microbiology Unit, Trieste University Hospital (ASUGI), Trieste, Italy.; Dodaro S; Microbiology and Virology Unit, 'Annunziata' Hospital of Cosenza, Cosenza, Italy.; Fiori B; Dipartimento Di Scienze Di Laboratorio E Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; García-Fernández A; Department of Infectious Diseases, Istituto Superiore Di Sanità, Rome, Italy.; Foschi C; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.; Gobbato E; Laboratory of Microbiology and Virology, Azienda Ospedaliero Universitaria Maggiore Della Carità, Corso Mazzini 18, Novara, Italy.; Greco F; Microbiology and Virology Unit, 'Annunziata' Hospital of Cosenza, Cosenza, Italy.; La Ragione RM; School of Veterinary Medicine, University of Surrey, Guildford, UK.; School of Biosciences, University of Surrey, Guildford, UK.; Mancini N; Laboratory of Medical Microbiology and Virology, Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy.; Laboratory of Medical Microbiology and Virology, Fondazione Macchi University Hospital, Varese, Italy.; Maraolo AE; First Division of Infectious Diseases, Cotugno Hospital, AORN Dei Colli, Naples, Italy.; Marchese A; Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.; Microbiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Marcuccio D; Microbiology and Virology Unit, Great Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy.; Marrollo R; Clinical Microbiology Laboratory, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.; Mauri C; Clinical Microbiology and Virology Unit, 'A. Manzoni' Hospital, Lecco, Italy.; Mazzariol A; Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Di Verona, Verona, Italy.; Morroni G; Microbiology Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.; Mosca A; Interdisciplinary Department of Medicine (DIM), University of Bari 'Aldo Moro', Policlinico, Bari, Italy.; Nigrisoli G; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Pagani E; Laboratorio Aziendale Di Microbiologia E Virologia, Comprensorio Sanitario Di Bolzano, Azienda Sanitaria Dell'Alto Adige, Bolzano, Italy.; Parisio EM; Microbiology Analysis Unit, San Donato Hospital, USL Toscana Sud Est, Arezzo, Italy.; Pollini S; Microbiology and Virology Unit, Careggi University Hospital, Florence, Italy.; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Sarti M; Clinical Microbiology and Virology Unit, AOU Policlinico, Modena, Italy.; Sorrentino A; Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Di Verona, Verona, Italy.; Trotta D; Microbiology Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.; Villa L; Department of Infectious Diseases, Istituto Superiore Di Sanità, Rome, Italy.; Vismara C; Clinical Microbiology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.; Principe L; Microbiology and Virology Unit, Great Metropolitan Hospital 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy.
Source
Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-4373 (Electronic) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE
Subject
Language
English
Abstract
Purpose: Campylobacter is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human Campylobacter infections in Italy during the period 2017-2021.
Methods: Data was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).
Results: In total, 5419 isolations of Campylobacter spp. were performed. The most common species were C. jejuni (n = 4535, 83.7%), followed by C. coli (n = 732, 13.5%) and C. fetus (n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected. Campylobacter were isolated from faeces in 97.3% of cases and in 2.7% from blood. C. fetus was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of C. jejuni and C. coli were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p < 0.005), while resistance to macrolides remained stable.
Conclusion: Campylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Methods: Data was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).
Results: In total, 5419 isolations of Campylobacter spp. were performed. The most common species were C. jejuni (n = 4535, 83.7%), followed by C. coli (n = 732, 13.5%) and C. fetus (n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected. Campylobacter were isolated from faeces in 97.3% of cases and in 2.7% from blood. C. fetus was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of C. jejuni and C. coli were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p < 0.005), while resistance to macrolides remained stable.
Conclusion: Campylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)