학술논문
Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study.
Document Type
Academic Journal
Author
Najioullah F; CHU de Martinique, Pôle de Biologie - Pathologie, Laboratoire de Virologie, Martinique, France.; Dorival MJ; Laboratoire de Pathologie SERAL, Fort-de-France, Martinique, France.; Joachim C; CHU de Martinique, Pôle de Cancérologie Hématologie Urologie, UF1441 Registre Général des cancers de la Martinique, Martinique, France.; Dispagne C; Residence de Cluny, Martinique, France.; Macni J; CHU de Martinique, Pôle de Cancérologie Hématologie Urologie, UF1441 Registre Général des cancers de la Martinique, Martinique, France.; Abel S; Service de Maladies Infectieuses et Tropicales, CHU de Martinique, Martinique, France.; Sulpicy C; Laboratoire de Pathologie SERAL, Fort-de-France, Martinique, France.; Charpentier-Baltide H; Rue Victor Schoelcher, Martinique, France.; Sainte-Rose D; CHU de Martinique, Martinique, France.; Salomon-Frechou B; Avenue François Mitterand, Martinique, France.; Dieye M; Centre Hospitalier Angoulême, Angoulême, France.; Véronique-Baudin J; CHU de Martinique, Pôle de Cancérologie Hématologie Urologie, UF1441 Registre Général des cancers de la Martinique, Martinique, France.; Pré M; All Lauriers, Le Robert, Martinique, France.; Marquet M; Route de Redoute, Martinique, France.; Wan-Ajouhu G; CHU de Martinique, Martinique, France.; Janky E; CHU de Guadeloupe-Laboratory CELTEC Cancer and Environment EA4546, Université des Antilles, Guadeloupe, France.; Riethmuller D; Service de Gynécologie Obstétrique, CHRU de Besançon - Hôpital Jean Minjoz, Besançon, France.; Cesaire R; CHU de Martinique, Pôle de Biologie - Pathologie, Laboratoire de Virologie, Martinique, France.
Source
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Subject
Language
English
Abstract
The Caribbean ranks seventh among the world regions most affected by cervical cancer. HPV-prevalence and genotype distributions also differ from regions. Knowledge of HPV genotype profiles is important for patients care and HPV vaccination implementation. The objective of this study was to describe HPV genotype distribution and risk factors in a population-based cohort of women in Martinique. In this study, 1312 women were included and underwent cervical cancer screening with successful sample collection between 2009 and 2014. Sociodemographic and clinical variables were recorded. Cytological examination of cervical vaginal smear was performed and classified(Bethesda). Detection of HPV DNA was performed with the PapilloCheck© Kit from Greiner Bio-one. Genotypes were analyzed for18 high-risk HPV (hrHPV) and 6low-risk HPV(lrHPV) types. A total of 1075 women were included with a mean age of 49.1±10.5 years. HPV prevalence was 27.6% (297/1075) with 19.4% (209/1075) women with only hrHPV, 5.3% (57/1075) with only lrHPV. Multiple infections (hrHPV/lrHPV) were detected in 31/240 cases of hrHPV (12.9%). A total of 353 hrHPV genotypes were analyzed; the most common HPV types were HPV51 (11.0%), HPV68 (10.8%), HPV53 (9.1%) and HPV 52 (7.1%). HPV16 and HPV18 represented respectively 4.8% and 4.0% of hrHPV genotypes. Abnormal cytology was observed in 34 cases (3.2%), with 14 ASCUS (1.3%), 10 LSIL (0.9%), 5 HSIL (0.5%), 3 ASC-H (0.3%) and 2 AGC (0.2%). Fifteen (44.1%) were hrHPV and 4 (14.7%) lrHPV; 7 cases of hrPHV were in the age-group 25-34 years. Among 1041cases of normal cytology, 225 had positive hrHPV detection (21.6%). This is the first population-based study of HPV profiles in our country, and we found a high prevalence of hrHPV. The most common genotypes were HPV51, 68, 53. These results could serve for cancer vaccination strategies and HPV surveillance in Martinique.
Competing Interests: The authors have declared that no competing interests exist.
Competing Interests: The authors have declared that no competing interests exist.