학술논문
Effectiveness of a single-dose mass dengue vaccination in Cebu, Philippines: A case-control study.
Document Type
Academic Journal
Author
Ylade M; Institute of Child Health and Human Development, National Institutes of Health, University of the Philippines - Manila, Philippines, Pedro Gil St., Ermita, Manila, Philippines. Electronic address: mcylade@up.edu.ph.; Agrupis KA; Institute of Child Health and Human Development, National Institutes of Health, University of the Philippines - Manila, Philippines, Pedro Gil St., Ermita, Manila, Philippines.; Daag JV; Institute of Child Health and Human Development, National Institutes of Health, University of the Philippines - Manila, Philippines, Pedro Gil St., Ermita, Manila, Philippines.; Crisostomo MV; Institute of Child Health and Human Development, National Institutes of Health, University of the Philippines - Manila, Philippines, Pedro Gil St., Ermita, Manila, Philippines.; Tabuco MO; Institute of Child Health and Human Development, National Institutes of Health, University of the Philippines - Manila, Philippines, Pedro Gil St., Ermita, Manila, Philippines.; Sy AK; Department of VirologyResearch Institute for Tropical Medicine, Muntinlupa, Philippines.; Nealon J; Sanofi Pasteur, Lyon, France.; Macina D; Sanofi Pasteur, Lyon, France.; Sarol J; Interdisciplinary Health Sciences Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Deen J; Institute of Child Health and Human Development, National Institutes of Health, University of the Philippines - Manila, Philippines, Pedro Gil St., Ermita, Manila, Philippines.; Lopez AL; Institute of Child Health and Human Development, National Institutes of Health, University of the Philippines - Manila, Philippines, Pedro Gil St., Ermita, Manila, Philippines.
Source
Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Dengue fever is an important public health problem in the Philippines. In April 2016, the Department of Health launched a three-dose school based dengue vaccination program of nine- to fourteen-year-old children in three regions with the highest number of dengue cases using CYD-TDV (Dengvaxia, Sanofi Pasteur). In July 2017, a community-based dengue vaccination program was implemented in Cebu province. The program was discontinued in December 2017 amidst public controversy, after the first dose had been administered. We assessed the effectiveness of a single dose of CYD-TDV against hospitalized virologically confirmed dengue (VCD).
Methods: We conducted a case-control study in Cebu province following the dengue mass vaccination. Children who were nine to fourteen years of age during the mass vaccination and subsequently admitted to any of four participating public hospitals with suspected dengue were enrolled in the study as cases. Blood for RT-PCR and clinical and socio-demographic information were obtained. To estimate the level of vaccine protection, vaccination status was compared between children with hospitalized virologically confirmed dengue and controls of the same six-year age-group as the cases, matched on sex, neighborhood and time of occurrence of cases.
Findings: We enrolled 490 cases and 980 controls. Receipt of one dose of CYD-TDV was associated with 26% (95 % CI, -2 to 47%; p = 0 0675) overall protection against hospitalized virologically confirmed dengue and 51% (95 % CI, 23 to 68; p = 0 0016) protection against dengue with warning signs.
Interpretation: A single dose of CYD-TDV given to nine to fourteen-year-old children through a community-based mass vaccination program conferred protection against dengue with warning signs and severe dengue but we were unable to conclude on protection against milder illness.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Methods: We conducted a case-control study in Cebu province following the dengue mass vaccination. Children who were nine to fourteen years of age during the mass vaccination and subsequently admitted to any of four participating public hospitals with suspected dengue were enrolled in the study as cases. Blood for RT-PCR and clinical and socio-demographic information were obtained. To estimate the level of vaccine protection, vaccination status was compared between children with hospitalized virologically confirmed dengue and controls of the same six-year age-group as the cases, matched on sex, neighborhood and time of occurrence of cases.
Findings: We enrolled 490 cases and 980 controls. Receipt of one dose of CYD-TDV was associated with 26% (95 % CI, -2 to 47%; p = 0 0675) overall protection against hospitalized virologically confirmed dengue and 51% (95 % CI, 23 to 68; p = 0 0016) protection against dengue with warning signs.
Interpretation: A single dose of CYD-TDV given to nine to fourteen-year-old children through a community-based mass vaccination program conferred protection against dengue with warning signs and severe dengue but we were unable to conclude on protection against milder illness.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)