학술논문
Introduction of SARS-CoV-2 C.37 (WHO VOI lambda) in the Sao Paulo State, Southeast Brazil.
Document Type
Academic Journal
Author
Kashima S; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Slavov SN; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Butantan Institute, São Paulo, Brazil.; Giovanetti M; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Instituto Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.; Rodrigues ES; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Patané JSL; Butantan Institute, São Paulo, Brazil.; Viala VL; Butantan Institute, São Paulo, Brazil.; Santos EV; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Evaristo M; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; de Lima LPO; Butantan Institute, São Paulo, Brazil.; Martins AJ; Butantan Institute, São Paulo, Brazil.; Dos Santos Barros CR; Butantan Institute, São Paulo, Brazil.; Marqueze EC; Butantan Institute, São Paulo, Brazil.; Garibaldi PMM; Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Serrana State Hospital, Serrana, Brazil.; Ferreira NN; Serrana State Hospital, Serrana, Brazil.; Moraes GR; Epidemic Service, Serrana, Brazil.; Brassaloti RA; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba, SP, Brazil.; Cassano RLRC; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba, SP, Brazil.; Mariani PDSC; NGS Soluções Genômicas, Piracicaba, SP, Brazil.; Kitajima JP; Mendelics Análise Genômica SA, Sao Paulo, Brazil.; Schlesinger D; Mendelics Análise Genômica SA, Sao Paulo, Brazil.; Bezerra RS; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Assato PA; Department of Bioprocesses and Biotechnology, School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu, Brazil.; da Costa FAS; Department of Bioprocesses and Biotechnology, School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu, Brazil.; Poleti MD; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga, Brazil.; Lesbon JCC; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga, Brazil.; Mattos EC; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga, Brazil.; Banho CA; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.; Sacchetto L; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.; Grotto RMT; School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu, Brazil.; Molecular Biology Laboratory, Applied Biotechnology Laboratory, Clinical Hospital of the Botucatu Medical School, Botucato, Brazil.; Souza-Neto JA; School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu, Brazil.; Fonseca V; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Coordenação Geral de Laboratórios de Saúde Pública/Secretaria de Vigilância em Saúde, Ministério da Saúde, (CGLAB/SVS-MS) Brasília, Brazil.; de Alcantara LCJ; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Instituto Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.; Nogueira ML; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.; Fukumasu H; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga, Brazil.; Coutinho LL; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba, SP, Brazil.; Borges M; Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Serrana State Hospital, Serrana, Brazil.; Calado RT; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Elias MC; Butantan Institute, São Paulo, Brazil.; Sampaio SC; Butantan Institute, São Paulo, Brazil.; Covas DT; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.; Butantan Institute, São Paulo, Brazil.; Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Source
Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
Subject
Language
English
Abstract
The Lambda variants of interest (VOI) (C37/GR/452Q.V1/21G) was initially reported in Lima, Peru but has gained rapid dissemination through other Latin American countries. Nevertheless, the dissemination and molecular epidemiology of the Lambda VOI in Brazil is unknown apart from a single case report. In this respect, we characterized the circulation of the SARS-CoV-2 Lambda VOI (C37/GR/452Q.V1/21G) in Sao Paulo State, Brazil. From March to June 2021, we identified seven Lambda isolates in a set of approximately 8000 newly sequenced genomes of the Network for Pandemic Alert of Emerging SARS-CoV-2 variants from Sao Paulo State. Interestingly, in three of the positive patients, the Lambda VOI infection was probably related to a contact transmission. These individuals were fully vaccinated to COVID-19 and presented mild symptoms. The remaining positive for Lambda VOI individuals showed different levels of COVID-19 symptoms and one of them needed hospitalization (score 5, WHO). In our study, we present a low level of Lambda VOI circulation in the Sao Paulo State. This reinforces the essential role of molecular surveillance for the effective SARS-CoV-2 pandemic response, especially in regard to circulating variants.
(© 2021 Wiley Periodicals LLC.)
(© 2021 Wiley Periodicals LLC.)