학술논문
Chikungunya virus as a trigger for different renal disorders: an exploratory study.
Document Type
Academic Journal
Author
do Nascimento Costa DM; Nephrology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil. denisecosta_81@yahoo.com.; Machado CE; University Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.; Neves PD; Divisions of Nephrology and Molecular Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.; Brito DJ; University Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.; Oi S; University Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.; Barros FH; University Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.; Figueiredo LT; Virology Department, Ribeirão , Preto Medical School of the University of São Paulo, Ribeirão Preto, São Paulo, Brazil.; Almeida Araujo S; Microscopy Center of the Federal University of Minas Gerais and Institute of Nephropathology, Belo Horizonte, Minas Gerais, Brazil.; Ladchumananandasivam F; University Hospital of the Federal University of Paraiba, João Pessoa, Paraíba, Brazil.; Dos Reis MA; Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.; Luchi W; Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.; Lages J; University Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.; Filho NS; University Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.; Onuchic LF; Divisions of Nephrology and Molecular Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.; Duarte AL; Rheumatology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.; Marques CDL; Rheumatology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.; Coêlho MRCD; Virology Division, Laboratory of Immunopathology Keizo Asami of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.; Oliveira C; Nephrology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.; Vajgel G; Nephrology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.; Cavalcante MA; Nephrology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.; Valente L; Nephrology Department, Hospital das Clínicas of the Federal University of Pernambuco, Recife, Pernambuco, Brazil.; Magalhães V; Department of Tropical Medicine, Federal University of Pernambuco, Recife, Pernambuco, Brazil.; Silva GEB; University Hospital of the Federal University of Maranhão, São Luís, Maranhão, Brazil.
Source
Publisher: Springer Country of Publication: Italy NLM ID: 9012268 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-6059 (Electronic) Linking ISSN: 11218428 NLM ISO Abbreviation: J Nephrol Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: Chikungunya virus was detected in cases of acute chikungunya fever in renal tissue. However, chikungunya virus-related kidney injury still lacks characterization, and it is unknown whether the kidneys are reservoirs for the virus. We sought to detect histopathological changes and viral antigens in renal tissue, and to evaluate kidney injury markers in different phases of chikungunya fever.
Methods: Two groups were evaluated in this exploratory study: patients with biopsy-proven kidney injury established after chikungunya fever, and patients with post-chikungunya fever chronic joint manifestations without known kidney injury, in whom we actively searched for kidney injury markers.
Results: In the first group, 15 patients had kidney injury 0.5-24 months after chikungunya fever. The most frequent histopathological diagnoses were glomerular lesions. No viral antigens were detected in renal tissue. High-risk genotypes were detected in patients with atypical hemolytic uremic syndrome and focal and segmental glomerulosclerosis. In the second group, 114 patients had post-chikungunya fever joint manifestations on average for 35.6 months. Mean creatinine and proteinuria were 0.9 mg/dl and 71.5 mg/day, respectively. One patient had isolated hematuria. There was no indication for renal biopsy in this group.
Conclusions: Several histopathological features were found after chikungunya fever, without virus detection in renal tissue. These findings suggest that chikungunya virus may trigger kidney lesions with varying degrees of severity at different stages of infection. However, the probability that this virus replicates in the renal tissue seems unlikely.
(© 2022. The Author(s) under exclusive licence to Italian Society of Nephrology.)
Methods: Two groups were evaluated in this exploratory study: patients with biopsy-proven kidney injury established after chikungunya fever, and patients with post-chikungunya fever chronic joint manifestations without known kidney injury, in whom we actively searched for kidney injury markers.
Results: In the first group, 15 patients had kidney injury 0.5-24 months after chikungunya fever. The most frequent histopathological diagnoses were glomerular lesions. No viral antigens were detected in renal tissue. High-risk genotypes were detected in patients with atypical hemolytic uremic syndrome and focal and segmental glomerulosclerosis. In the second group, 114 patients had post-chikungunya fever joint manifestations on average for 35.6 months. Mean creatinine and proteinuria were 0.9 mg/dl and 71.5 mg/day, respectively. One patient had isolated hematuria. There was no indication for renal biopsy in this group.
Conclusions: Several histopathological features were found after chikungunya fever, without virus detection in renal tissue. These findings suggest that chikungunya virus may trigger kidney lesions with varying degrees of severity at different stages of infection. However, the probability that this virus replicates in the renal tissue seems unlikely.
(© 2022. The Author(s) under exclusive licence to Italian Society of Nephrology.)