학술논문
Digital Microscopy Augmented by Artificial Intelligence to Interpret Bone Marrow Samples for Hematological Diseases.
Document Type
Academic Journal
Author
Bermejo-Peláez D; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.; Rueda Charro S; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.; García Roa M; Department of Hematology, Hospital Universitario Fundación Alcorcón, C. Budapest, 1, Alcorcón 28922, Madrid, Spain.; Trelles-Martínez R; Department of Hematology, Hospital Universitario Fundación Alcorcón, C. Budapest, 1, Alcorcón 28922, Madrid, Spain.; Bobes-Fernández A; Department of Hematology, Hospital Universitario Fundación Alcorcón, C. Budapest, 1, Alcorcón 28922, Madrid, Spain.; Hidalgo Soto M; Vall Hebron Institute of Oncology (VHIO), Carrer de Natzaret, 115-117, Horta-Guinardó, Barcelona 08035, Spain.; García-Vicente R; Department of Translational Hematology, Research Institute Hospital 12 de Octubre (imas12), Av. de Córdoba, s/n, Madrid 28041, Spain.; Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.; Morales ML; Department of Translational Hematology, Research Institute Hospital 12 de Octubre (imas12), Av. de Córdoba, s/n, Madrid 28041, Spain.; Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.; Rodríguez-García A; Department of Translational Hematology, Research Institute Hospital 12 de Octubre (imas12), Av. de Córdoba, s/n, Madrid 28041, Spain.; Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.; Ortiz-Ruiz A; Department of Translational Hematology, Research Institute Hospital 12 de Octubre (imas12), Av. de Córdoba, s/n, Madrid 28041, Spain.; Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.; Blanco Sánchez A; Department of Hematology, Hospital Universitario 12 de Octubre, Av. de Córdoba, s/n, Madrid 28041, Spain.; Mousa Urbina A; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.; Álamo E; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.; Lin L; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.; Biomedical Image Technologies Laboratory, ETSI Telecomunicación, Universidad Politécnica de Madrid, Av. Complutense, 30, Madrid 28040, Spain.; Dacal E; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.; Cuadrado D; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.; Postigo M; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.; Vladimirov A; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.; Garcia-Villena J; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.; Santos A; Biomedical Image Technologies Laboratory, ETSI Telecomunicación, Universidad Politécnica de Madrid, Av. Complutense, 30, Madrid 28040, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.; Ledesma-Carbayo MJ; Biomedical Image Technologies Laboratory, ETSI Telecomunicación, Universidad Politécnica de Madrid, Av. Complutense, 30, Madrid 28040, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.; Ayala R; Department of Translational Hematology, Research Institute Hospital 12 de Octubre (imas12), Av. de Córdoba, s/n, Madrid 28041, Spain.; Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.; Department of Hematology, Hospital Universitario 12 de Octubre, Av. de Córdoba, s/n, Madrid 28041, Spain.; Martínez-López J; Department of Translational Hematology, Research Institute Hospital 12 de Octubre (imas12), Av. de Córdoba, s/n, Madrid 28041, Spain.; Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.; Department of Hematology, Hospital Universitario 12 de Octubre, Av. de Córdoba, s/n, Madrid 28041, Spain.; Linares M; Department of Translational Hematology, Research Institute Hospital 12 de Octubre (imas12), Av. de Córdoba, s/n, Madrid 28041, Spain.; Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.; Department of Biochemistry and Molecular Biology, Pharmacy School, Universidad Complutense de Madrid, Pl. de Ramón y Cajal, s/n, Madrid 28040, Spain.; Luengo-Oroz M; Spotlab, P.º de Juan XXIII, 36B, Madrid 28040, Spain.
Source
Publisher: Oxford University Press Country of Publication: England NLM ID: 9712707 Publication Model: Print Cited Medium: Internet ISSN: 1435-8115 (Electronic) Linking ISSN: 14319276 NLM ISO Abbreviation: Microsc Microanal Subsets: MEDLINE
Subject
Language
English
Abstract
Analysis of bone marrow aspirates (BMAs) is an essential step in the diagnosis of hematological disorders. This analysis is usually performed based on a visual examination of samples under a conventional optical microscope, which involves a labor-intensive process, limited by clinical experience and subject to high observer variability. In this work, we present a comprehensive digital microscopy system that enables BMA analysis for cell type counting and differentiation in an efficient and objective manner. This system not only provides an accessible and simple method to digitize, store, and analyze BMA samples remotely but is also supported by an Artificial Intelligence (AI) pipeline that accelerates the differential cell counting process and reduces interobserver variability. It has been designed to integrate AI algorithms with the daily clinical routine and can be used in any regular hospital workflow.
Competing Interests: Conflict of Interest D.B.-P., S.R.C., A.M.U., E.A., L.L., E.D., DC, M.P., A.V., J.G.-V., M.J.L.-C., A.S., M.L., and M.L.-O. hold shares or phantom shares of Spotlab. The rest of the authors declare that they have no competing interest.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the Microscopy Society of America.)
Competing Interests: Conflict of Interest D.B.-P., S.R.C., A.M.U., E.A., L.L., E.D., DC, M.P., A.V., J.G.-V., M.J.L.-C., A.S., M.L., and M.L.-O. hold shares or phantom shares of Spotlab. The rest of the authors declare that they have no competing interest.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the Microscopy Society of America.)