학술논문
Perioperative Analgesia and Patients' Satisfaction in Spinal Anesthesia for Cesarean Section: Fentanyl Versus Morphine.
Document Type
Academic Journal
Author
Botea MO; Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.; Pelican Clinic, Medicover Hospital, 4104869 Oradea, Romania.; Lungeanu D; Center for Modeling Biological Systems and Data Analysis, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.; Department of Functional Sciences, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.; Petrica A; Department of Surgery, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.; Emergency Department, 'Pius Brinzeu' Emergency Clinical County Hospital, 300736 Timisoara, Romania.; Sandor MI; Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.; Huniadi AC; Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.; Pelican Clinic, Medicover Hospital, 4104869 Oradea, Romania.; Barsac C; Department of Surgery, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.; Clinic of Anaesthesia and Intensive Care, 'Pius Brinzeu' Emergency Clinical County Hospital, 300736 Timisoara, Romania.; Marza AM; Department of Surgery, 'Victor Babes' University of Medicine and Pharmacy, 300041 Timisoara, Romania.; Emergency Department, Emergency Clinical Municipal Hospital, 300079 Timisoara, Romania.; Moisa RC; Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.; Maghiar L; Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.; Botea RM; Oradea County Clinical Emergency Hospital, 410169 Oradea, Romania.; Macovei CI; Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.; Pelican Clinic, Medicover Hospital, 4104869 Oradea, Romania.; Bimbo-Szuhai E; Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.; Pelican Clinic, Medicover Hospital, 4104869 Oradea, Romania.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2077-0383
Abstract
Perioperative analgesia for cesarean section aims to ensure the mother's comfort, facilitate a smooth surgical experience, and promote a successful recovery. One-hundred-ninety patients were enrolled in a randomized double-blind study designed to assess the quality of perioperative analgesia, level of satisfaction, and incidence of adverse reactions in elective cesarean section under spinal anesthesia when fentanyl or morphine was added to bupivacaine. Two treatment groups comprising 173 subjects were compared in the per-protocol analysis: F (fentanyl, standard dose 25 μg) and M (morphine, standard dose 100 μg). Numerical pain scores were recorded perioperatively for 72 h (both at rest and on mobilization), with overall postoperative satisfaction and analgesic-related side effects. The patients in the morphine group had significantly better pain management (Mann-Whitney U test, p < 0.001) and higher level of satisfaction (Mann-Whitney U test, p < 0.001). The latter was related to the greater need for rescue medication in the fentanyl group (OR = 4.396; p = 0.019). On the other hand, fentanyl had significantly fewer non-life-threatening side effects, such as high-intensity pruritus (Mann-Whitney U test, p < 0.001), nausea (OR = 0.324; p = 0.019), vomiting and dizziness upon first mobilization (OR = 0.256; p < 0.001). It remains for future clinical trials to help establish doses that will tilt the scale to one side or the other.