학술논문

Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»).
Document Type
Academic Journal
Author
Tarlovskaya EI; Eurasian Association of Therapists, Moscow; Privolzhsky Research Medical University, Nizhny Novgorod.; Arutyunov AG; Eurasian Association of Therapists, Moscow; N. I. Pirogov Russian National Research Medical University, Moscow.; Konradi AO; V. A. Almazov National Medical Research Center, St. Peterburg.; Lopatin YM; Volgograd State Medical University, Volgograd.; Rebrov AP; V. I. Razumovsky Saratov State Medical University, Saratov.; Tereshchenko SN; National Medical Research Center of Cardiology, Moscow.; Chesnikova AI; Rostov State Medical University, Rostov-on-Don.; Hayrapetyan HG; Erebouni Medical Center, Cardiology and Cardiac Surgery Clinic, Erevan.; Babin AP; Nikolae Testemitanu Sate University of Medicine and Pharmacy, Kishinev.; Bakulin IG; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Bakulina NV; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Balykova LA; N. P. Ogarev National Research Mordovia State University, Saransk.; Blagonravova AS; Privolzhsky Research Medical University, Nizhny Novgorod.; Boldina MV; Privolzhsky Research Medical University, Nizhny Novgorod.; Vaisberg AR; Privolzhsky Research Medical University, Nizhny Novgorod.; Galyavich AS; Interregional Clinical Diagnostic Center, Kazan; Kazan State Medical University, Kazan.; Gomonova VV; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Grigorieva NY; N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod.; Gubareva IV; Samara State Medical University, Samara.; Demko IV; Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk.; Evzerikhina AV; Krasnogorsk Municipal Hospital №1, Krasnogorsk.; Zharkov AV; Kirovsk Inter-District Hospital, Kirovsk.; Kamilova UK; National Specialized Science and Practice Medical Center for Therapy and Medical Rehabilitation, Tashkent.; Kim ZF; Kazan Municipal Clinical Hospital №7, Kazan.; Kuznetsova TY; Petrozavodsk State University, Petrozavodsk.; Lareva NV; Chita State Medical Academy, Chita.; Makarova EV; Privolzhsky Research Medical University, Nizhny Novgorod.; Malchikova SV; Kirov State Medical University, Kirov.; Nedogoda SV; Volgograd State Medical University, Volgograd.; Petrova MM; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk.; Pochinka IG; Privolzhsky Research Medical University, Nizhny Novgorod; Municipal Clinical Hospital #13 of the Nizhny Novgorod Avtozavodsky District, Nizhny Novgorod.; Protasov KV; Irkutsk State Medical Academy of Postgraduate Education, Branch of the Russian Medical Academy of Continuing Professional Education, Irkutsk.; Protsenko DN; Municipal Clinical Hospital №40, Moscow.; Ruzanau DY; Gomel State Medical University, Gome.; Sayganov SA; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Sarybaev AS; M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek.; Selezneva NM; N. P. Ogarev National Research Mordovia State University, Saransk.; Sugraliev AB; S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata.; Fomin IV; Privolzhsky Research Medical University, Nizhny Novgorod.; Khlynova OV; Akademician E. A. Vagner Perm State Medical University, Perm.; Chizhova OY; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Shaposhnik II; South Ural State Medical University, Chelyabinsk.; Shсukarev DA; Kirovsk Inter-District Hospital, Kirovsk.; Abdrahmanova AK; Kazakh Medical University of Continuous Education, Alma-Ata; I. Zhekenova Municipal Clinical Hospital for Infectious Diseases, Alma-Ata.; Avetisian SA; Erebouni Medical Center, Cardiology and Cardiac Surgery Clinic, Erevan.; Avoyan HG; Erebouni Medical Center, Cardiology and Cardiac Surgery Clinic, Erevan.; Azarian KK; Erebouni Medical Center, Cardiology and Cardiac Surgery Clinic, Erevan.; Aimakhanova GT; S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata.; Ayipova DA; M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek.; Akunov AC; M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek.; Alieva MK; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Aparkina AV; V. I. Razumovsky Saratov State Medical University, Saratov.; Aruslanova OR; Clinical Cardiological Center, Perm.; Ashina EY; Privolzhsky Research Medical University, Nizhny Novgorod.; Badina OY; Privolzhsky District Medical Center, Nizhny Novgorod.; Barisheva OY; Petrozavodsk State University, Petrozavodsk.; Batchayeva AS; N. I. Pirogov Russian National Research Medical University, Moscow.; Bitieva AM; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Bikhteyev IU; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Borodulina NA; Clinical Cardiological Center, Perm.; Bragin MV; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Budu AM; Municipal Clinical Hospital №1, Kishinev.; Burygina LA; P. B. Gannushkin Psychiatric Clinical Hospital №4, Moscow.; Bykova GA; Akademician E. A. Vagner Perm State Medical University, Perm.; Vagapova KR; Polyclinic №1 at the Administrative Department of the President of the Russian Federation, Moscow.; Varlamova DD; Petrozavodsk State University, Petrozavodsk.; Vezikova NN; Petrozavodsk State University, Petrozavodsk.; Verbitskaya EA; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk.; Vilkova OE; N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod.; Vinnikova EA; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Vustina VV; Perm Regional Clinical Hospital, Perm.; Gаlova EA; Privolzhsky Research Medical University, Nizhny Novgorod.; Genkel VV; South Ural State Medical University, Chelyabinsk.; Gorshenina EI; N. P. Ogarev National Research Mordovia State University, Saransk.; Gostishev RV; Municipal Clinical Hospital №40, Moscow.; Grigorieva EV; V. I. Razumovsky Saratov State Medical University, Saratov.; Gubareva EY; Samara State Medical University, Samara.; Dabylova GM; S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata.; Demchenko AI; Samara State Medical University, Samara.; Dolgikh OY; Chapaevsk Central Municipal Hospital, Chapaevsk.; Duyshobayev MY; S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata.; Evdokimov DS; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Egorova KE; V. A Baranov Karelia Republic Hospital, Petrozavodsk.; Ermilova AN; Eurasian Association of Therapists, Moscow; V. P. Serbsky National Medical Research Center of Psychiatry and Narcology, Moscow.; Zheldybayeva AE; S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata.; Zarechnova NV; Privolzhsky District Medical Center, Nizhny Novgorod.; Zimina YD; Municipal Clinical Hospital №25, Novosibirsk.; Ivanova SY; Hospital for Veterans of Wars, Petrozavodsk.; Ivanchenko EY; Privolzhsky Research Medical University, Nizhny Novgorod.; Ilina MV; Kirovsk Inter-District Hospital, outpatient department, Kirovsk.; Kazakovtseva MV; Kirov State Medical University, Kirov.; Kazymova EV; Clinical Hospital at the Samara Station 'Russian Railways Medicine', Samara.; Kalinina YS; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk.; Kamardina NA; Privolzhsky District Medical Center, Nizhny Novgorod.; Karachenova AM; Chita State Medical Academy, Chita.; Karetnikov IA; Irkutsk Regional Clinical Hospital, recipient of the 'Badge of Honor' award, Irkutsk.; Karoli NA; V. I. Razumovsky Saratov State Medical University, Saratov.; Karpov OV; P. B. Gannushkin Psychiatric Clinical Hospital #4, Moscow.; Karsiev MK; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Кaskaeva DS; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk.; Kasymova KF; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk.; Kerimbekova ZB; M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek.; Kerimova AS; Municipal Clinical Hospital №40, Moscow.; Kim ES; Kazan State Medical University, Kazan; Kazan Municipal Clinical Hospital №7, Kazan.; Kiseleva NV; Privolzhsky Research Medical University, Nizhny Novgorod.; Klimenko DA; Samara State Medical University, Samara.; Klimova AV; N. I. Pirogov Russian National Research Medical University, Moscow; Municipal Polyclinic №134, Moscow.; Kovalishena OV; Privolzhsky Research Medical University, Nizhny Novgorod.; Kolmakova EV; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Kolchinskaya TP; Chelyabinsk Municipal Clinical Hospital №1, Chelyabinsk.; Kolyadich MI; South Ural State Medical University, Chelyabinsk; Chelyabinsk Municipal Clinical Hospital №1, Chelyabinsk.; Kondriakova OV; Samara State Medical University, Samara.; Konoval MP; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Konstantinov DY; Samara State Medical University, Samara.; Konstantinova EA; Samara State Medical University, Samara.; Kordukova VA; Privolzhsky Research Medical University, Nizhny Novgorod.; Koroleva EV; Municipal Clinical Hospital №5 of the Nizhny Novgorod Nizhegorodsky District, Nizhny Novgorod.; Kraposhina AY; Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk.; Kriukova TV; Eurasian Association of Therapists, Moscow.; Kuznetsova AS; South Ural State Medical University, Chelyabinsk.; Kuzmina TY; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk.; Kuzmichev KV; Municipal Clinical Hospital №13 of the Nizhny Novgorod Avtozavodsky District, Nizhny Novgorod.; Kulchoroeva CK; M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek.; Kuprina TV; Petrozavodsk State University, Petrozavodsk.; Kouranova IM; Gorodets Central Regional Hospital, Gorodets.; Kurenkova LV; S. V. Katkov Mordovian Clinical Hospital, Saransk.; Kurchugina NY; Samara State Medical University, Samara.; Kushubakova NA; M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek.; Levankova VI; Municipal Polyclinic №1, Petrozavodsk.; Levin MЕ; P. B. Gannushkin Psychiatric Clinical Hospital №4, Moscow.; Lyubavina NA; Privolzhsky Research Medical University, Nizhny Novgorod.; Magdeyeva NA; V. I. Razumovsky Saratov State Medical University, Saratov.; Mazalov KV; Privolzhsky District Medical Center, Nizhny Novgorod.; Majseenko VI; Gomel State Medical University, Gomel.; Makarova AS; Irkutsk State Medical Academy of Postgraduate Education, Branch of the Russian Medical Academy of Continuing Professional Education, Irkutsk.; Maripov AM; M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek.; Marusina AA; Kirovsk Inter-District Hospital, outpatient department, Kirovsk.; Melnikov ES; Eurasian Association of Therapists, Moscow; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Moiseenko NB; N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod.; Muradova FN; Privolzhsky Research Medical University, Nizhny Novgorod.; Muradyan RG; Global Medical System Clinics and Hospitals, Moscow.; Myshak AO; MedInvestGroup LLC, Moscow.; Nikitina NM; V. I. Razumovsky Saratov State Medical University, Saratov.; Ogurlieva BB; N. I. Pirogov Russian National Research Medical University, Moscow; Municipal Clinical Hospital №4, Moscow.; Odegova AA; Kirov State Medical University, Kirov.; Omarova YM; Privolzhsky Research Medical University, Nizhny Novgorod.; Omurzakova NA; M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek.; Ospanova SO; S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata.; Pahomova EV; GBUZ RK 'Republican tuberculosis dispensary', Petrozavodsk.; Petrov LD; Health Center Brichen, Brichen.; Plastinina SS; Privolzhsky Research Medical University, Nizhny Novgorod.; Pogrebetskaya VA; Municipal Clinical Hospital №38 of the Nizhny Novgorod Nizhegorodsky District, Nizhny Novgorod.; Polyakov DS; Privolzhsky Research Medical University, Nizhny Novgorod.; Ponomarenko EV; Medical Center 'Zimamed', Krasnodar.; Popova LL; Samara State Medical University, Samara.; Prokofeva NA; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Pudova IA; Privolzhsky Research Medical University, Nizhny Novgorod; Municipal Polyclinic №4 of the Nizhny Novgorod Kanavinsky District, Nizhny Novgorod.; Rakov NA; Privolzhsky Research Medical University, Nizhny Novgorod.; Rakhimov AN; 21 National Specialized Science and Practice Medical Center for Therapy and Medical Rehabilitation, Tashkent.; Rozanova NA; Krasnogorsk Municipal Hospital №1, Krasnogorsk.; Serikbolkyzy S; S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata.; Simonov AA; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Skachkova VV; Perm Regional Clinical Hospital, Perm.; Soloveva DV; Privolzhsky Research Medical University, Nizhny Novgorod.; Soloveva IA; Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk.; Sokhova FM; P. B. Gannushkin Psychiatric Clinical Hospital №4, Moscow.; Subbotin AK; Privolzhsky District Medical Center, Nizhny Novgorod.; Sukhomlinova IM; Hospital for Veterans of Wars, St. Petersburg.; Sushilova AG; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Tagayeva DR; National Specialized Science and Practice Medical Center for Therapy and Medical Rehabilitation, Tashkent.; Titojkina YV; N. P. Ogarev National Research Mordovia State University, Saransk.; Tikhonova EP; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk.; Tokmin DS; AO 'Laboratories of the Future', Moscow.; Tolmacheva AA; Novosibirsk State Medical University, Novosibirsk; Clinical Consultative and Diagnostic Polyclinic №27, Novosibirsk.; Torgunakova MS; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk.; Trenogina KV; Perm Regional Clinical Hospital, Perm.; Trostianetckaia NA; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Trofimov DA; Kazan State Medical University, Kazan; Kazan Municipal Clinical Hospital №7, Kazan.; Tulichev AA; Privolzhsky Research Medical University, Nizhny Novgorod; Municipal Clinical Hospital №3, Nizhny Novgorod.; Tursunova AT; S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata.; Ulanova ND; Municipal Clinical Hospital #13 of the Nizhny Novgorod Avtozavodsky District, Nizhny Novgorod.; Fatenkov OV; Samara State Medical University, Samara.; Fedorishina OV; Irkutsk State Medical Academy of Postgraduate Education, Branch of the Russian Medical Academy of Continuing Professional Education, Irkutsk.; Fil TS; I. I. Mechnikov North-Western State Medical University, St. Petersburg.; Fomina IY; Privolzhsky Research Medical University, Nizhny Novgorod; Municipal Polyclinic #1, Nizhny Novgorod.; Fominova IS; N. P. Ogarev National Research Mordovia State University, Saransk.; Frolova IA; Privolzhsky District Medical Center, Nizhny Novgorod.; Tsvinger SM; Chita State Medical Academy, Chita.; Tsoma VV; Volgograd State Medical University, Volgograd.; Cholponbaeva MB; M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek.; Chudinovskikh TI; Kirov State Medical University, Kirov.; Shevchenko OA; Samara Municipal Polyclinic №3, Samara.; Sheshina TV; N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod.; Shishkina EA; Akademician E. A. Vagner Perm State Medical University, Perm.; Shishkov KY; Samara State Medical University, Samara.; Sherbakov SY; Kazan State Medical Academy, Branch of the Russian Medical Academy of Continuing Professional Education, Kazan.; Yausheva EA; N. P. Ogarev National Research Mordovia State University, Saransk.; Musaelian SN; Erevan State Medical University, Erevan.; Belenkov YN; The First Moscow state medical University I. M. Sechenov.; Arutyunov GP; Eurasian Association of Therapists, Moscow; N. I. Pirogov Russian National Research Medical University, Moscow.
Source
Publisher: OOO "Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti Country of Publication: Russia (Federation) NLM ID: 0376351 Publication Model: Electronic Cited Medium: Print ISSN: 0022-9040 (Print) Linking ISSN: 00229040 NLM ISO Abbreviation: Kardiologiia Subsets: MEDLINE
Subject
Language
Russian; English
ISSN
0022-9040
Abstract
Aim      To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material and methods  The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients' privacy (data of nasal and throat smears; antibody titer; typical CT imaging features). The register territory included 7 countries: the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan. The registry design: a closed, multicenter registry with two nonoverlapping arms (outpatient arm and in-patient arm). The registry scheduled 6 visits, 3 in-person visits during the acute period and 3 virtual visits (telephone calls) at 3, 6, and 12 mos. Patient enrollment started on June 29, 2020 and was completed on October 29, 2020. The registry completion is scheduled for October 29, 2022. The registry ID: ClinicalTrials.gov: NCT04492384. In this fragment of the study of registry data, the work group analyzed the effect of therapy for comorbidities at baseline on severity and outcomes of the novel coronavirus infection. The study population included only the patients who took their medicines on a regular basis while the comparison population consisted of noncompliant patients (irregular drug intake or not taking drugs at all despite indications for the treatment).Results The analysis of the ACTIVE registry database included 5808 patients. The vast majority of patients with COVID-19 had comorbidities with prevalence of cardiovascular diseases. Medicines used for the treatment of COVID-19 comorbidities influenced the course of the infectious disease in different ways. A lower risk of fatal outcome was associated with the statin treatment in patients with ischemic heart disease (IHD); with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists and with beta-blockers in patients with IHD, arterial hypertension, chronic heart failure (CHF), and atrial fibrillation; with oral anticoagulants (OAC), primarily direct OAC, clopidogrel/prasugrel/ticagrelor in patients with IHD; with oral antihyperglycemic therapy in patients with type 2 diabetes mellitus (DM); and with long-acting insulins in patients with type 1 DM. A higher risk of fatal outcome was associated with the spironolactone treatment in patients with CHF and with inhaled corticosteroids (iCS) in patients with chronic obstructive pulmonary disease (COPD).Conclusion      In the epoch of COVID-19 pandemic, a lower risk of severe course of the coronavirus infection was observed for patients with chronic noninfectious comorbidities highly compliant with the base treatment of the comorbidity.