학술논문
Serum and urine levels of activin A in primigravidae and multigravidae: a prospective cross-sectional study.
Document Type
Academic Journal
Author
Casalechi M; Department of Obstetrics and Gynecology, Section of Reproductive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Coimbra BB; Department of Obstetrics and Gynecology, Section of Reproductive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Rocha DM; Department of Obstetrics and Gynecology, Section of Reproductive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Carvalho FR; Department of Obstetrics and Gynecology, Section of Reproductive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Clarizia AD; Department of Obstetrics and Gynecology, Section of Reproductive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Assis WA; Department of Obstetrics and Gynecology, Section of Reproductive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Aguiar RALP; Department of Obstetrics and Gynecology, Section of Reproductive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Reis FM; Department of Obstetrics and Gynecology, Section of Reproductive Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Source
Publisher: Routledge Country of Publication: United States NLM ID: 7608076 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-0331 (Electronic) Linking ISSN: 03630242 NLM ISO Abbreviation: Women Health Subsets: MEDLINE
Subject
Language
English
Abstract
The aim of the present study was to investigate serum and urine levels of activin A in different moments of gestation, in primigravidae and in multigravidae, to understand whether these variables (biological sample and first gestation) affect activin A as a biomarker in pregnancy. We prospectively included 43 pairs of serum and urine samples from 25 women examined at different gestational ages (range 45 to 268 days). In the group of primigravidae (n = 16 samples from 9 participants), there was no significant change in serum activin A levels across gestation. Conversely, the group of multigravidae (n = 27 samples from 16 women) had higher serum activin A levels in the third trimester (2676 ± 840 pg/ml) compared to the first (583 ± 408 pg/ml) and second (1040 ± 384) trimesters ( p = .025). Urine activin A concentrations did not differ between the two groups and did not change according to the gestation phase. There was no correlation between serum and urinary levels of activin A (r = 0.149, p = .359). These data suggest that activin A secretion may vary less during the first pregnancy, while urine activin A is unlikely to be a surrogate for the systemic levels of this hormone in pregnant women.