학술논문
Arbovirus circulation among febrile patients at the greater Accra Regional Hospital, Ghana.
Document Type
Academic Journal
Author
Manu SK; Department of Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.; Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, P.O. Box LG 581, Accra, Ghana.; Bonney JHK; Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, P.O. Box LG 581, Accra, Ghana. kbonney@noguchi.ug.edu.gh.; Pratt D; Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, P.O. Box LG 581, Accra, Ghana.; Abdulai FN; Public Health Department, Greater Accra Regional Hospital, Ridge, Accra, Ghana.; Agbosu EE; Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, P.O. Box LG 581, Accra, Ghana.; Frimpong PO; Public Health Department, Greater Accra Regional Hospital, Ridge, Accra, Ghana.; Adiku TK; Department of Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.; Department of Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.
Source
Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: Arboviruses, Dengue and Chikungunya have become major international public health concerns due to their epidemics and introduction in new areas. In Ghana, little is known is about Dengue and Chikungunya viruses though the country has been listed as part of the 34 countries in which the viruses are endemic. This has been attributed partly to the lack of diagnostic tools for these viruses in several health facilities and institutions across the country. The purpose of this study was to detect and characterize these viral pathogens among febrile patients in Accra Ghana.
Results: This hospital-based cross-sectional study enrolled 260 suspected Dengue and/or Chikungunya febrile patients who submitted their clinical specimens of serum. Out of the total number tested with both molecular and serological tools, Chikungunya and Dengue specific total antibodies were detected from 72 (27.69%) and 180 (69.23%) respectively. None of the participants tested positive for Dengue and Chikungunya by reverse transcription-polymerase chain reaction (RT-PCR) and with the Dengue-specific NS1 antigen strip kits. Our findings suggested that Dengue and Chikungunya viruses may be circulating but are being missed among febrile patients. Differential diagnosis work-up in febrile patients should be made to include Dengue and Chikungunya infections.
Results: This hospital-based cross-sectional study enrolled 260 suspected Dengue and/or Chikungunya febrile patients who submitted their clinical specimens of serum. Out of the total number tested with both molecular and serological tools, Chikungunya and Dengue specific total antibodies were detected from 72 (27.69%) and 180 (69.23%) respectively. None of the participants tested positive for Dengue and Chikungunya by reverse transcription-polymerase chain reaction (RT-PCR) and with the Dengue-specific NS1 antigen strip kits. Our findings suggested that Dengue and Chikungunya viruses may be circulating but are being missed among febrile patients. Differential diagnosis work-up in febrile patients should be made to include Dengue and Chikungunya infections.