학술논문
Maternal vitamin D status in pregnancy and molar incisor hypomineralisation and hypomineralised second primary molars in the offspring at 7-9 years of age: a longitudinal study.
Document Type
Academic Journal
Author
Børsting T; Center for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, Norway. torbo@tkmidt.no.; Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. torbo@tkmidt.no.; Schuller A; Department of Child Health, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.; Centre of Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; van Dommelen P; Department of Child Health, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.; Stafne SN; Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Clinical Service, Trondheim University Hospital (St. Olavs Hospital), Trondheim, Norway.; Skeie MS; Center for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, Norway.; Department of Clinical Dentistry, University of Bergen, Bergen, Norway.; Skaare AB; Department of Paediatric Dentistry and Behavioural Science, Faculty of Dentistry, University of Oslo, Oslo, Norway.; Mørkved S; Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Clinical Service, Trondheim University Hospital (St. Olavs Hospital), Trondheim, Norway.; Salvesen KÅ; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Obstetrics and Gynaecology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway.; Stunes AK; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Medical Clinic, Trondheim University Hospital (St. Olavs Hospital), Trondheim, Norway.; Mosti MP; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Medical Clinic, Trondheim University Hospital (St. Olavs Hospital), Trondheim, Norway.; Gustafsson MK; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Regional Education Center (RegUt), Helse Midt-Norge, Trondheim, Norway.; Syversen U; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Endocrinology, Trondheim University Hospital (St. Olavs Hospital), Trondheim, Norway.; Fagerhaug TN; Center for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, Norway.; Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Source
Publisher: Springer Country of Publication: England NLM ID: 101277157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1996-9805 (Electronic) Linking ISSN: 18186300 NLM ISO Abbreviation: Eur Arch Paediatr Dent Subsets: MEDLINE
Subject
Language
English
Abstract
Purpose: The study aimed to investigate associations between maternal vitamin D status during pregnancy and molar incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM) among children.
Methods: The study had a longitudinal design using prospectively collected data from 176 mother and child pairs. Mothers were initially recruited in a randomised controlled trial to assess a pregnancy exercise programme. Along with the 7-year follow-up, we invited the children to a dental examination. The exposure variable was maternal serum 25-hydroxyvitamin D in gestational weeks 18-22 and 32-36, categorised as insufficient (< 50 nmol/l) and sufficient (≥ 50 nmol/l). Negative binomial hurdle models were used to analyse potential associations between the exposure variables and MIH or HSPM. The models were adjusted for potential confounders.
Results: Among the children (7-9 years old), 32% and 22% had at least one tooth with MIH or HSPM, respectively. A significant association was found between insufficient maternal vitamin D measured in gestational weeks 18-22 and the number of affected teeth among those with MIH at 7-9 years (adjusted RR = 1.82, 95% CI 1.13-2.93).
Conclusion: Considering any limitations of the present study, it has been shown that insufficient maternal serum vitamin D at mid-pregnancy was associated with a higher number of affected teeth among the offspring with MIH at 7-9 years of age. Further prospective studies are needed to investigate whether this finding is replicable and to clarify the role of maternal vitamin D status during pregnancy and MIH, as well as HSPM, in children.
(© 2022. The Author(s).)
Methods: The study had a longitudinal design using prospectively collected data from 176 mother and child pairs. Mothers were initially recruited in a randomised controlled trial to assess a pregnancy exercise programme. Along with the 7-year follow-up, we invited the children to a dental examination. The exposure variable was maternal serum 25-hydroxyvitamin D in gestational weeks 18-22 and 32-36, categorised as insufficient (< 50 nmol/l) and sufficient (≥ 50 nmol/l). Negative binomial hurdle models were used to analyse potential associations between the exposure variables and MIH or HSPM. The models were adjusted for potential confounders.
Results: Among the children (7-9 years old), 32% and 22% had at least one tooth with MIH or HSPM, respectively. A significant association was found between insufficient maternal vitamin D measured in gestational weeks 18-22 and the number of affected teeth among those with MIH at 7-9 years (adjusted RR = 1.82, 95% CI 1.13-2.93).
Conclusion: Considering any limitations of the present study, it has been shown that insufficient maternal serum vitamin D at mid-pregnancy was associated with a higher number of affected teeth among the offspring with MIH at 7-9 years of age. Further prospective studies are needed to investigate whether this finding is replicable and to clarify the role of maternal vitamin D status during pregnancy and MIH, as well as HSPM, in children.
(© 2022. The Author(s).)