학술논문
Comparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use?
Document Type
Academic Journal
Author
Taha A; Division of Experimental Cardiology, Department of Cardiology (A.T., J.B., D.J.D., H.M.M.v.B.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Stroke Center (A.T., D.W.J.D.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Bobi J; Division of Experimental Cardiology, Department of Cardiology (A.T., J.B., D.J.D., H.M.M.v.B.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Dammers R; Department of Neurosurgery, Stroke Center (R.D., V.V.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Dijkhuizen RM; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, the Netherlands (R.M.D.).; Dreyer AY; Max Planck Institute for Infection Biology, Campus Charité Mitte, Berlin, Germany (A.Y.D.).; van Es ACGM; Department of Radiology, Leiden University Medical Center, the Netherlands (A.C.G.M.v.E.).; Ferrara F; Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany (F.F.).; Gounis MJ; Department of Radiology, New England Center for Stroke Research, University of Massachusetts Medical School, Worcester (M.J.G.).; Nitzsche B; Institute of Anatomy, Faculty of Veterinary Medicine (B.N.), University of Leipzig, Germany.; Department of Nuclear Medicine (B.N.), University of Leipzig, Germany.; Platt S; Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens (S.P.).; Stoffel MH; Division of Veterinary Anatomy, Vetsuisse Faculty, University of Bern, Switzerland (M.H.S.).; Volovici V; Department of Neurosurgery, Stroke Center (R.D., V.V.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Del Zoppo GJ; Division of Hematology (G.J.d.Z.), University of Washington School of Medicine, Seattle.; Department of Medicine (G.J.d.Z.), University of Washington School of Medicine, Seattle.; Department of Neurology (G.J.d.Z.), University of Washington School of Medicine, Seattle.; Duncker DJ; Division of Experimental Cardiology, Department of Cardiology (A.T., J.B., D.J.D., H.M.M.v.B.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Dippel DWJ; Department of Neurology, Stroke Center (A.T., D.W.J.D.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Boltze J; School of Life Sciences, Faculty of Science, University of Warwick, Coventry, United Kingdom (J.B.).; van Beusekom HMM; Division of Experimental Cardiology, Department of Cardiology (A.T., J.B., D.J.D., H.M.M.v.B.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Source
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE
Subject
Language
English
Abstract
Translation of acute ischemic stroke research to the clinical setting remains limited over the last few decades with only one drug, recombinant tissue-type plasminogen activator, successfully completing the path from experimental study to clinical practice. To improve the selection of experimental treatments before testing in clinical studies, the use of large gyrencephalic animal models of acute ischemic stroke has been recommended. Currently, these models include, among others, dogs, swine, sheep, and nonhuman primates that closely emulate aspects of the human setting of brain ischemia and reperfusion. Species-specific characteristics, such as the cerebrovascular architecture or pathophysiology of thrombotic/ischemic processes, significantly influence the suitability of a model to address specific research questions. In this article, we review key characteristics of the main large animal models used in translational studies of acute ischemic stroke, regarding (1) anatomy and physiology of the cerebral vasculature, including brain morphology, coagulation characteristics, and immune function; (2) ischemic stroke modeling, including vessel occlusion approaches, reproducibility of infarct size, procedural complications, and functional outcome assessment; and (3) implementation aspects, including ethics, logistics, and costs. This review specifically aims to facilitate the selection of the appropriate large animal model for studies on acute ischemic stroke, based on specific research questions and large animal model characteristics.