학술논문
[The research progress of high altitude environment-associated chronic obstructive pulmonary disease and therapeutic drugs].
Document Type
Academic Journal
Author
Zeng XH; Department of Pharmacy, the 940th Hospital of the Joint Logistic Support Force, Lanzhou 730050, China.; School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.; Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China.; Suonan GL; Department of Internal Medicine, Qinghai Yushu People's Hospital, Yushu 815099, China.; Huang Q; Department of Pharmacy, the 940th Hospital of the Joint Logistic Support Force, Lanzhou 730050, China.; Li Y; Department of Pharmacy, the 940th Hospital of the Joint Logistic Support Force, Lanzhou 730050, China.; School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.; Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China.; Zhang XJ; Department of Pharmacy, the 940th Hospital of the Joint Logistic Support Force, Lanzhou 730050, China.; Li WB; Department of Pharmacy, the 940th Hospital of the Joint Logistic Support Force, Lanzhou 730050, China.; School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.; Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China.; Wang R; Department of Pharmacy, the 940th Hospital of the Joint Logistic Support Force, Lanzhou 730050, China.; School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.; Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China. wangrong-69@163.com.
Source
Publisher: Science Press Country of Publication: China NLM ID: 20730130R Publication Model: Print Cited Medium: Internet ISSN: 0371-0874 (Print) Linking ISSN: 03710874 NLM ISO Abbreviation: Sheng Li Xue Bao Subsets: MEDLINE
Subject
Language
Chinese
ISSN
0371-0874
Abstract
The plateau environment is characterized by low oxygen, low air pressure, low temperature, and strong ultraviolet rays, etc. Chronic obstructive pulmonary disease (COPD) is a preventable and treatable chronic lung disease. High altitude environment increases COPD prevalence, clinical manifestation and mortality. The therapeutic window of theophylline drugs for COPD is narrow, and the high altitude environment has an influence on the pharmacokinetics of the drugs. This review summarizes the differences in the prevalence, mortality, clinical manifestation and clinical symptoms of COPD in the plateau and plain, providing a basis for identifying the risk factors of COPD in the plateau areas. The effects of plateau hypoxic environment on the pharmacokinetics of COPD drugs were also discussed. It can provide a rationale for more effective prevention and treatment of COPD at high altitude.