학술논문
Recurrence of primitive germ cell tumour 20 years on.
Document Type
Academic Journal
Author
Younan HC; Department of Clinical Oncology, Imperial College Healthcare NHS Trust, London, UK helen-cara.younan@nhs.net.; Keogh G; Department of Medical Oncology, Imperial College Healthcare NHS Trust, London, UK.; Seckl M; Department of Medical Oncology, Imperial College Healthcare NHS Trust, London, UK.; Faculty of Medicine, Imperial College London, London, UK.; Sarwar N; Department of Medical Oncology, Imperial College Healthcare NHS Trust, London, UK.; Faculty of Medicine, Imperial College London, London, UK.
Source
Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE
Subject
Language
English
Abstract
We present a case of a woman in her 20s, with a prior history of paediatric sacrococcygeal germ cell tumour, presenting with a 6-month history of perianal pain. An MRI pelvis revealed a heterogeneous soft tissue mass causing destruction of the sacrococcygeal bone. A staging CT demonstrated metastatic deposits in the lungs and hypodense foci in the liver suspicious of metastatic disease. Her alpha-fetoprotein levels were raised and a CT-guided biopsy was in keeping with recurrent germ cell tumour. She was referred to a national centre for the treatment of germ cell tumours in adults and was rechallenged with cisplatin-based multiagent chemotherapy with a curative intent. This case raises the important question of how long we should follow-up these patients and whether they can ever be safely discharged from oncology surveillance.
Competing Interests: Competing interests: None declared.
(© BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
Competing Interests: Competing interests: None declared.
(© BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.)