학술논문
Lithium-induced Nephrogenic Diabetes Insipidus with Efficacy of Desmopressin in Combination with Thiazide Diuretics and Non-steroidal Anti-inflammatory Drugs: A Case Report with a Review of the Literature.
Document Type
Academic Journal
Author
Jinnouchi T; Department of Endocrinology and Diabetes, NTT Medical Center Tokyo, Japan.; Yoshimoto M; Department of Endocrinology and Diabetes, NTT Medical Center Tokyo, Japan.; Ogino K; Department of Psychosomatic Medicine, NTT Medical Center Tokyo, Japan.; Oji T; Department of Psychosomatic Medicine, NTT Medical Center Tokyo, Japan.; Hayashi M; Department of Endocrinology and Diabetes, NTT Medical Center Tokyo, Japan.
Source
Publisher: Japanese Society of Internal Medicine Country of Publication: Japan NLM ID: 9204241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7235 (Electronic) Linking ISSN: 09182918 NLM ISO Abbreviation: Intern Med Subsets: MEDLINE
Subject
Language
English
Abstract
Nephrogenic diabetes insipidus (NDI) is characterized by excessive urination and an inability to concentrate urine. Lithium is the most common cause of acquired NDI. Treatment typically involves thiazide diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs). However, the efficacy of desmopressin in NDI remains unclear. We herein report a case of lithium-induced NDI in a 71-year-old woman with lithium-induced NDI. Thiazide diuretics and NSAIDs reduced the urine output by approximately 40% compared to pretreatment, while the addition of desmopressin reduced it by approximately 70%. This case suggests that desmopressin can be a viable treatment option for lithium-induced NDI.