학술논문
A cyclical switch of gametogenic pathways in hybrids depends on the ploidy level.
Document Type
Academic Journal
Author
Dedukh D; Laboratory of Non-Mendelian Evolution, Institute of Animal Physiology and Genetics of the CAS, Liběchov, Czech Republic. dmitrijdedukh@gmail.com.; Marta A; Laboratory of Non-Mendelian Evolution, Institute of Animal Physiology and Genetics of the CAS, Liběchov, Czech Republic.; Myung RY; Division of EcoScience, Ewha Womans University, Seoul, South Korea.; Ko MH; Kosoo Ecology Institute, Seoul, South Korea.; Choi DS; Division of EcoScience, Ewha Womans University, Seoul, South Korea.; Won YJ; Division of EcoScience, Ewha Womans University, Seoul, South Korea.; Janko K; Laboratory of Non-Mendelian Evolution, Institute of Animal Physiology and Genetics of the CAS, Liběchov, Czech Republic. Janko@iapg.cas.cz.; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic. Janko@iapg.cas.cz.
Source
Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Subject
Language
English
Abstract
The cellular and molecular mechanisms governing sexual reproduction are conserved across eukaryotes. Nevertheless, hybridization can disrupt these mechanisms, leading to asexual reproduction, often accompanied by polyploidy. In this study, we investigate how ploidy level and ratio of parental genomes in hybrids affect their reproductive mode. We analyze the gametogenesis of sexual species and their diploid and triploid hybrids from the freshwater fish family Cobitidae, using newly developed cytogenetic markers. We find that diploid hybrid females possess oogonia and oocytes with original (diploid) and duplicated (tetraploid) ploidy. Diploid oocytes cannot progress beyond pachytene due to aberrant pairing. However, tetraploid oocytes, which emerge after premeiotic genome endoreplication, exhibit normal pairing and result in diploid gametes. Triploid hybrid females possess diploid, triploid, and haploid oogonia and oocytes. Triploid and haploid oocytes cannot progress beyond pachytene checkpoint due to aberrant chromosome pairing, while diploid oocytes have normal pairing in meiosis, resulting in haploid gametes. Diploid oocytes emerge after premeiotic elimination of a single-copied genome. Triploid hybrid males are sterile due to aberrant pairing and the failure of chromosomal segregation during meiotic divisions. Thus, changes in ploidy and genome dosage may lead to cyclical alteration of gametogenic pathways in hybrids.
(© 2024. The Author(s).)
(© 2024. The Author(s).)