학술논문
The Mount Sinai Clinical Pathway for the Diagnosis and Management of Hypercortisolism due to Ectopic ACTH Syndrome.
Document Type
Report
Author
Alba EL; The Adrenal Center, Division of Endocrine, Diabetes and Bone Diseases, Department of Medicine at the Icahn School of Medicine at Mount Sinai, New York , NY, USA.; Japp EA; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine at the University of Maryland School of Medicine, Baltimore, MD, USA.; Fernandez-Ranvier G; Division of Metabolic, Endocrine, and Minimally Invasive Surgery, Department of Surgery at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Badani K; Division of Urology, Department of Surgery at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Wilck E; Department of Diagnostic, Molecular and Interventional Radiology at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ghesani M; Department of Diagnostic, Molecular and Interventional Radiology at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Wolf A; Division of Thoracic Surgery, Department of Surgery at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Wolin EM; The Center for Carcinoid and Neuroendocrine Tumors, Tisch Cancer Institute, Division of Hematology and Oncology, Department of Medicine at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Corbett V; Division of Hematology and Oncology, Department of Medicine at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Steinmetz D; Division of Metabolic, Endocrine, and Minimally Invasive Surgery, Department of Surgery at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Skamagas M; The Adrenal Center, Division of Endocrine, Diabetes and Bone Diseases, Department of Medicine at the Icahn School of Medicine at Mount Sinai, New York , NY, USA.; Levine AC; The Adrenal Center, Division of Endocrine, Diabetes and Bone Diseases, Department of Medicine at the Icahn School of Medicine at Mount Sinai, New York , NY, USA.
Source
Publisher: Endocrine Society Country of Publication: United States NLM ID: 101697997 Publication Model: eCollection Cited Medium: Internet ISSN: 2472-1972 (Electronic) Linking ISSN: 24721972 NLM ISO Abbreviation: J Endocr Soc Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Neoplasms that secrete ectopic adrenocorticotropin (ACTH) may cause severe, life-threatening hypercortisolism. These tumors are often difficult to localize and treat, requiring a comprehensive and systematic management plan orchestrated by a multidisciplinary team. The Mount Sinai Adrenal Center hosted an interdisciplinary retreat of experts in adrenal disorders and neuroendocrine tumors (NETs) with the aim of developing a clinical pathway for the management of Cushing syndrome due to ectopic ACTH production. The result was institutional recommendations for the diagnosis, localization, surgical approaches to intrathoracic tumors and bilateral adrenalectomy, and perioperative and postoperative medical management of hypercortisolism and its sequelae. Specific recommendations were made regarding the timing and selection of therapies based on the considerations of our team as well as a review of the current literature. Our clinical pathway can be applied by other institutions directly or serve as a guide for institution-specific management.
(© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.)
(© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.)