학술논문
Differential Diagnosis of Diarrhea in Patients With Neuroendocrine Tumors.
Document Type
Academic Journal
Author
Eads JR; From the Department of Medicine, Division of Hematology and Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.; Reidy-Lagunes D; Department of Medicine, Division of Solid Tumor, Gastrointestinal Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY.; Soares HP; Division of Medical Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.; Chan JA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Anthony LB; Division of Medical Oncology, University of Kentucky Medical Center, Markey Cancer Center, Lexington, KY.; Halfdanarson TR; Division of Medical Oncology, Mayo Clinic Cancer Center, Rochester, MN.; Naraev BG; Division of Cancer Medicine, Banner MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Gilbert, AZ.; Wolin EM; Department of Medicine, Division of Hematology/Oncology, Icahn School of Medicine, Center for Carcinoid and Neuroendocrine Tumors, Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY.; Halperin DM; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Li D; Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA.; Pommier RF; Division of Surgical Oncology, Oregon Health & Science University, Portland, OR.; Zacks JS; Department of Medicine (Cardiology), The Mount Sinai School of Medicine, The Carcinoid Heart Center, New York, NY.; Morse MA; Department of Medical Oncology, Duke University Medical Center, Durham, NC.; Metz DC; Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Source
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8608542 Publication Model: Print Cited Medium: Internet ISSN: 1536-4828 (Electronic) Linking ISSN: 08853177 NLM ISO Abbreviation: Pancreas Subsets: MEDLINE
Subject
Language
English
Abstract
Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience diarrhea that can have a debilitating effect on quality of life. Diarrhea also may develop in response to other hormonal syndromes associated with NETs, surgical complications, medical comorbidities, medications, or food sensitivities. Limited guidance on the practical approach to the differential diagnosis of diarrhea in these patients can lead to delays in appropriate treatment. This clinical review and commentary underscore the complexity in identifying the etiology of diarrhea in patients with NETs. Based on our collective experience and expertise, we offer a practical algorithm to guide medical oncologists and other care providers to expedite effective management of diarrhea and related symptoms in patients with NETs.