학술논문
Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations.
Document Type
Academic Journal
Author
Petry CJ; Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. cjp1002@cam.ac.uk; Evans ML; Wingate DL; Ong KK; Reik W; Constância M; Dunger DB
Source
Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101274844 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1687-5303 (Electronic) Linking ISSN: 16875214 NLM ISO Abbreviation: Exp Diabetes Res Subsets: MEDLINE
Subject
Language
English
Abstract
At the beginning of the third week of pregnancy, mouse fetuses with targeted disruption of their paternally-transmitted insulin-like growth factor 2 gene placental-specific transcripts have growth-restricted placentas but normal body weights due to upregulated placental nutrient transport. We assessed whether increased placental glucose transport rates were associated with raised maternal glucose concentrations by performing intraperitoneal glucose tolerance tests (ipGTT) in pregnant mice carrying knockout pups and comparing them with mice carrying genotype-matched phenotypically wild type pups. Mean ± SD body weights of affected pups were 95 ± 8% of control values at e16 and 73 ± 7% at e18. There were no differences in areas under the maternal ipGTT curves at either e16 (mean ± SD being 99.0 ± 9.1% of control values; P = .9) or e18 (91.4 ± 13.4%; P = .3), suggesting that effects on transplacental glucose transport in these mice are not mediated through changes in maternal glucose concentrations.