학술논문
Recent progress in asymmetric synergistic catalysis - the judicious combination of selected chiral aminocatalysts with achiral metal catalysts.
Document Type
Academic Journal
Author
Nielsen CD; Imperial College London, White City Campus, Molecular Sciences Research Hub (MSRH), 82 Wood Lane, London W12 0BZ, UK. a.c.spivey@imperial.ac.uk.; Linfoot JD; Imperial College London, White City Campus, Molecular Sciences Research Hub (MSRH), 82 Wood Lane, London W12 0BZ, UK. a.c.spivey@imperial.ac.uk.; Williams AF; Imperial College London, White City Campus, Molecular Sciences Research Hub (MSRH), 82 Wood Lane, London W12 0BZ, UK. a.c.spivey@imperial.ac.uk.; Spivey AC; Imperial College London, White City Campus, Molecular Sciences Research Hub (MSRH), 82 Wood Lane, London W12 0BZ, UK. a.c.spivey@imperial.ac.uk.
Source
Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE
Subject
Language
English
Abstract
In this review we survey recent synergistic applications of a chiral organocatalyst with an achiral metal to perform stereoselective transformations of synthetic utility (since 2016). The transformations are classified by the modes of reactivity deployed, focussing on organocatalytic activation of carbonyl substrates as chiral nucleophiles via the α-position ( e.g. , as enamines) and as chiral electrophiles via the β-position ( e.g. , as iminium ions) combined with complementary activation of their reaction partners by an achiral metal co-catalyst ( e.g. , Pd or Cu-based). Corresponding radical reactions are also presented in which photocatalysis mediated by achiral metal complexes replaces the metal co-catalyst. Certain privileged structures are revealed and opportunities to develop this exciting field are highlighted.