학술논문
Physicochemical, antidiarrheal and antidiabetic potential of super food (Moringa oleifera Lam.).
Document Type
Academic Journal
Author
Aziz I; Department of Pharmacy, COMSAT Institute of Information Technology, Abbot Abad, Pakistan.; Saqib QN; Department of Pharmacy, COMSAT Institute of Information Technology, Abbot Abad, Pakistan.; Younus M; Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, Pakistan.; Ali E; University College of Pharmacy, University of Punjab, Lahore, Pakistan.; Qadir MI; Institute of Molecular Biology & Biotechnology, Bahuddin Zakariya University, Multan, Pakistan.; Siddique FA; Department of Pharmacy, University of Central Punjab, Lahore, Pakistan.; Wazir MA; Department of Pharmacognosy, Faculty of Pharmacy, Bahuddin Zakariya University, Multan, Pakistan.; Shaheer MT; School of Pharmacy, Xian Jiaotong University, Xi'an, Shaanxi, China.; Adnan Q; Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, Pakistan.; Shirazi JH; Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, Pakistan.; Rehman KU; Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, Pakistan.; Ullah S; Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.; Abbas K; Department of Pharmacognosy, Faculty of Pharmacy, Bahuddin Zakariya University, Multan, Pakistan.
Source
Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Internet ISSN: 1011-601X (Print) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE
Subject
Language
English
ISSN
1011-601X
Abstract
There is a long history of natural products for the treatment of infections and diseases. The objective of present study was to investigate the organoleptic, microscopic, physico-chemical, phytochemical, antidiarrheal and antidiabetic potential of leaf, flowering bud and stem bark of Moringa oleifera L. Macroscopic, microscopic, physico-chemical parameters and phytochemical screening were carried out. Diarrhea was induced with castor oil (10ml/kg), verapamil (3, 10 and 30mg/kg) were used as standard antidiarrheal drug and extract of Moringa oleifera at (100, 300 and 1000mg/kg) was used for treatment. Alpha glucosidase inhibitory assay was carried out by using acarbose (0.5mM) and extracts (5.0 mg/Ml). Diabetes was induced by alloxan (150mg/kg), while glibenclamide (10mg/kg) was used as standard drug, and extracts (at the doses of 500mg/kg) were used to determine the antidiabetic activity. Results showed the presence of primary and secondary metabolites, treatment at the dose of 1.0g/kg of leaf, flowering bud and stem bark showed 94 ±2.527, 85.42±5.460 and 84.58±6.138% protection respectively whereas verapamil (10mg/kg) showed 94.84±3.27% protection. Alpha glucosidase inhibition of stem bark (0.5mg/ml) was 95.43±1.47 and flowering bud 94.78±1.25 whereas acarbose (5mM) inhibition was 92.23±0.14%. Stem bark and flowering bud extract (500mg/kg) decreases the blood glucose level from 388.5±35.83 to 226.3±47.10 and 322.5±48.35 to 173.8±29.5 respectively whereas glibenclamide (10 mg/kg) decreases the blood glucose level from 320.7±22.9 to 146.3±17.7 and increases the body weight of the experimental animal. It was concluded from the results that stem bark has strong antidiabetic potential while leaves of the plant have promising antidiarrheal effect.