학술논문
The effect of vibrotactile stimulation on hypoxia-induced irregular breathing and apnea in preterm rabbits.
Document Type
Academic Journal
Author
Cramer SJE; Willem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands. s.j.e.cramer@lumc.nl.; Dekker J; Willem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands.; Croughan MK; School of Physics and Astronomy, Monash University, Melbourne, VIC, Australia.; Lee KL; School of Physics and Astronomy, Monash University, Melbourne, VIC, Australia.; School of Earth and Environmental Science, University of Queensland, Brisbane, QLD, Australia.; Crossley KJ; The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.; Department of Obstetrics and Gynecology, Monash University, Melbourne, VIC, Australia.; McGillick EV; The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.; Department of Obstetrics and Gynecology, Monash University, Melbourne, VIC, Australia.; Martherus T; Willem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands.; Thio M; Women's Newborn Research Centre, The Royal Women's Hospital, Melbourne, VIC, Australia.; Centre of Research Excellence in Newborn Medicine, Murdoch Children's Research Institute, Melbourne, VIC, Australia.; Department of Obstetrics and Gynecology, University of Melbourne, Melbourne, VIC, Australia.; Wallace MJ; The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.; Department of Obstetrics and Gynecology, Monash University, Melbourne, VIC, Australia.; Kitchen MJ; School of Physics and Astronomy, Monash University, Melbourne, VIC, Australia.; The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.; Hooper SB; The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.; Department of Obstetrics and Gynecology, Monash University, Melbourne, VIC, Australia.; Te Pas AB; Willem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands.
Source
Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Manual tactile stimulation is used to counteract apnea in preterm infants, but it is unknown when this intervention should be applied. We compared an anticipatory to a reactive approach using vibrotactile stimulation to prevent hypoxia induced apneas.
Methods: Preterm rabbit kittens were prematurely delivered and randomized to either group. All kittens breathed spontaneously with a positive airway pressure of 8 cmH2 O while they were imaged using phase contrast X-ray. Irregular breathing (IB) was induced using gradual hypoxia. The anticipatory group received stimulation at the onset of IB and the reactive group if IB transitioned into apnea. Breathing rate (BR), heart rate (HR) and functional residual capacity (FRC) were compared.
Results: Anticipatory stimulation significantly reduced apnea incidence and maximum inter-breath intervals and increased BR following IB, compared to reactive stimulation. Recovery in BR but not HR was more likely with anticipatory stimulation, although both BR and HR were significantly higher at 120 s after stimulation onset. FRC values and variability were not different.
Conclusions: Anticipated vibrotactile stimulation is more effective in preventing apnea and enhancing breathing when compared to reactive stimulation in preterm rabbits. Stimulation timing is likely to be a key factor in reducing the incidence and duration of apnea.
Impact: Anticipated vibrotactile stimulation can prevent apnea and stimulate breathing effort in preterm rabbits. Anticipated vibrotactile stimulation increases the likelihood of breathing rate recovery following hypoxia induced irregular breathing, when compared to reactive stimulation. Automated stimulation in combination with predictive algorithms may improve the treatment of apnea in preterm infants.
(© 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
Methods: Preterm rabbit kittens were prematurely delivered and randomized to either group. All kittens breathed spontaneously with a positive airway pressure of 8 cmH
Results: Anticipatory stimulation significantly reduced apnea incidence and maximum inter-breath intervals and increased BR following IB, compared to reactive stimulation. Recovery in BR but not HR was more likely with anticipatory stimulation, although both BR and HR were significantly higher at 120 s after stimulation onset. FRC values and variability were not different.
Conclusions: Anticipated vibrotactile stimulation is more effective in preventing apnea and enhancing breathing when compared to reactive stimulation in preterm rabbits. Stimulation timing is likely to be a key factor in reducing the incidence and duration of apnea.
Impact: Anticipated vibrotactile stimulation can prevent apnea and stimulate breathing effort in preterm rabbits. Anticipated vibrotactile stimulation increases the likelihood of breathing rate recovery following hypoxia induced irregular breathing, when compared to reactive stimulation. Automated stimulation in combination with predictive algorithms may improve the treatment of apnea in preterm infants.
(© 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)