학술논문
Effect of prenatal diaphragmatic hernia on pulmonary arterial morphology.
Document Type
Academic Journal
Author
Stainsby AV; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.; DeKoninck PLJ; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynaecology, Erasmus MC University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.; Crossley KJ; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.; Thiel A; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; Wallace MJ; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.; Pearson JT; National Cerebral and Cardiovascular Center, Suita, Japan.; Department of Physiology, Victoria Heart Institute and Monash Biomedicine Institute, Monash University, Melbourne, Australia.; Kashyap AJ; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.; Croughan MK; School of Physics and Astronomy, Monash University, Melbourne, Australia.; Allison BA; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.; Hodges R; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.; Thio M; Newborn Research Centre, The Royal Women's Hospital, Melbourne, Australia.; The Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia.; Flemmer AW; Division of Neonatology Dr. von Hauner Children's Hospital and Perinatal Center, LMU University Hospital, Munich, Germany.; McGillick EV; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.; Te Pas AB; Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.; Hooper SB; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.; Kitchen MJ; Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.; School of Physics and Astronomy, Monash University, Melbourne, Australia.
Source
Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101292775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-8494 (Electronic) Linking ISSN: 19328486 NLM ISO Abbreviation: Anat Rec (Hoboken) Subsets: MEDLINE
Subject
Language
English
Abstract
Congenital diaphragmatic hernia (CDH) is a major cause of severe lung hypoplasia and pulmonary hypertension in the newborn. While the pulmonary hypertension is thought to result from abnormal vascular development and arterial vasoreactivity, the anatomical changes in vascular development are unclear. We have examined the 3D structure of the pulmonary arterial tree in rabbits with a surgically induced diaphragmatic hernia (DH). Fetal rabbits (n = 6) had a left-sided DH created at gestational day 23 (GD23), delivered at GD30, and briefly ventilated; sham-operated litter mates (n = 5) acted as controls. At postmortem the pulmonary arteries were filled with a radio-opaque resin before the lungs were scanned using computed tomography (CT). The 3D reconstructed images were analyzed based on vascular branching hierarchy using the software Avizo 2020.2. DH significantly reduced median number of arteries (2,579 (8440) versus 576 (442), p = .017), artery numbers per arterial generation, mean total arterial volume (43.5 ± 8.4 vs. 19.9 ± 3.1 μl, p = .020) and mean total arterial cross-sectional area (82.5 ± 2.3 vs. 28.2 ± 6.2 mm 2 , p =.036). Mean arterial radius was increased in DH kittens between the eighth and sixth branching generation and mean arterial length between the sixth and 28th branching generation. A DH in kittens resulted in threefold reduction in pulmonary arterial cross-sectional area, primarily due to reduced arterial branching. Thus, the reduction in arterial cross-sectional area could be a major contributor to pulmonary hypertension infants with CDH.
(© 2023 The Authors. The Anatomical Record published by Wiley Periodicals LLC on behalf of American Association for Anatomy.)
(© 2023 The Authors. The Anatomical Record published by Wiley Periodicals LLC on behalf of American Association for Anatomy.)