학술논문
Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial.
Document Type
Academic Journal
Author
Sakurai T; Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Department of Prevention and Care Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Department of Cognition and Behavior Science, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Sugimoto T; Department of Prevention and Care Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Department of Medicine, University of Washington, Seattle, Washington, USA.; Akatsu H; Department of General Medicine and General Internal Medicine, Nagoya City University Graduate School of Medicine, Nagoya, Aichi, Japan.; Doi T; Department of Preventive Gerontology, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Fujiwara Y; Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.; Hirakawa A; Department of Clinical Biostatistics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.; Kinoshita F; Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Aichi, Japan.; Kuzuya M; Meitetsu Hospital, Nagoya, Aichi, Japan.; Lee S; Department of Preventive Gerontology, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Department of Research, Obu Center for Dementia Care Research and Practice, Obu, Aichi, Japan.; Matsumoto N; Department of Prevention and Care Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Matsuo K; Department of Oral Health Sciences for Community Welfare, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.; Michikawa M; Department of Geriatric Medicine, School of Life Dentistry at Niigata, The Nippon Dental University, Niigata, Japan.; Nakamura A; Department of Biomarker Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Ogawa S; Research Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.; Otsuka R; Department of Epidemiology of Aging, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Sato K; Department of Rehabilitation Medicine, Hospital, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Shimada H; Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Suzuki H; Well Aging Division, Sompo Care Inc., Shinagawa-ku, Tokyo, Japan.; Suzuki H; Research Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.; Takechi H; Department of Geriatrics and Cognitive Disorders, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.; Takeda S; Department of Clinical Psychology, Tottori University Graduate School of Medical Sciences, Yonago, Tottori, Japan.; Uchida K; Department of Prevention and Care Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Umegaki H; Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Wakayama S; Department of Rehabilitation Medicine, Hospital, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Innovation for Aging & Wellness Department, Sompo Holdings, Inc., Shinagawa-Ku, Tokyo, Japan.; Arai H; National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Source
Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI).
Methods: Participants aged 65-85 years with MCI were randomized into intervention (management of vascular risk factors, exercise, nutritional counseling, and cognitive training) and control groups. The primary outcome was changes in the cognitive composite score over a period of 18 months.
Results: Of 531 participants, 406 completed the trial. The between-group difference in composite score changes was 0.047 (95% CI: -0.029 to 0.124). Secondary analyses indicated positive impacts of interventions on several secondary health outcomes. The interventions appeared to be particularly effective for individuals with high attendance during exercise sessions and those with the apolipoprotein E ε4 allele and elevated plasma glial fibrillary acidic protein levels.
Discussion: The multidomain intervention showed no efficacy in preventing cognitive decline. Further research on more efficient strategies and suitable target populations is required.
Highlights: This trial evaluated the efficacy of multidomain intervention in individuals with MCI. The trial did not show a significant difference in preplanned cognitive outcomes. Interventions had positive effects on a wide range of secondary health outcomes. Those with adequate adherence or high risk of dementia benefited from interventions.
(© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Methods: Participants aged 65-85 years with MCI were randomized into intervention (management of vascular risk factors, exercise, nutritional counseling, and cognitive training) and control groups. The primary outcome was changes in the cognitive composite score over a period of 18 months.
Results: Of 531 participants, 406 completed the trial. The between-group difference in composite score changes was 0.047 (95% CI: -0.029 to 0.124). Secondary analyses indicated positive impacts of interventions on several secondary health outcomes. The interventions appeared to be particularly effective for individuals with high attendance during exercise sessions and those with the apolipoprotein E ε4 allele and elevated plasma glial fibrillary acidic protein levels.
Discussion: The multidomain intervention showed no efficacy in preventing cognitive decline. Further research on more efficient strategies and suitable target populations is required.
Highlights: This trial evaluated the efficacy of multidomain intervention in individuals with MCI. The trial did not show a significant difference in preplanned cognitive outcomes. Interventions had positive effects on a wide range of secondary health outcomes. Those with adequate adherence or high risk of dementia benefited from interventions.
(© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)