학술논문
Associations among maternal lifetime trauma, psychological symptoms in pregnancy, and infant stress reactivity and regulation.
Document Type
Academic Journal
Author
Foss S; Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Petty CR; Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA, USA.; Howell C; Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA.; Mendonca J; Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA.; Bosse A; Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA.; Waber DP; Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Wright RJ; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Bosquet Enlow M; Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Source
Publisher: Cambridge University Press Country of Publication: United States NLM ID: 8910645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-2198 (Electronic) Linking ISSN: 09545794 NLM ISO Abbreviation: Dev Psychopathol Subsets: MEDLINE
Subject
Language
English
Abstract
Maternal trauma has intergenerational implications, including worse birth outcomes, altered brain morphology, and poorer mental health. Research investigating intergenerational effects of maternal trauma on infant stress reactivity and regulation is limited. Maternal mental health during pregnancy may be a contributor: psychopathology is a sequela of trauma exposure and predictor of altered self-regulatory capacity in offspring of affected mothers. We assessed associations among maternal lifetime trauma and infant stress responsivity, mediated by psychological symptoms in pregnancy. Mothers reported lifetime trauma history and anxiety, depressive, and posttraumatic stress symptoms during pregnancy. At infant age 6 months, stress reactivity and regulation were assessed via maternal behavior ratings (Infant Behavior Questionnaire-Revised, IBQ-R) and behavioral (negative mood) and physiological (respiratory sinus arrhythmia, RSA) markers during a laboratory stressor (Still-Face Paradigm). Maternal trauma was directly associated with lower infant physiological regulation and indirectly associated with lower levels of both infant behavioral and physiological regulation via higher maternal anxiety during pregnancy. Maternal trauma was also indirectly associated with higher infant reactivity via higher maternal anxiety during pregnancy. Post hoc analyses indicated differential contributions of maternal prenatal versus postnatal anxiety to infant outcomes. Findings highlight potential contributory mechanisms toward maladaptive child stress response, which has been associated with poor behavioral, cognitive, and academic outcomes.