학술논문
Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27-year-long longitudinal study.
Document Type
Academic Journal
Author
Samson LD; Centre for Infectious Disease Control National Institute for Public Health and the Environment Bilthoven The Netherlands.; Centre for Nutrition, Prevention and Health Services National Institute for Public Health and the Environment Bilthoven The Netherlands.; Department of Rheumatology and Clinical Immunology University Medical Center Groningen University of Groningen Groningen The Netherlands.; van den Berg SP; Centre for Infectious Disease Control National Institute for Public Health and the Environment Bilthoven The Netherlands.; Center for Translational Immunology University Medical Center Utrecht Utrecht The Netherlands.; Engelfriet P; Centre for Nutrition, Prevention and Health Services National Institute for Public Health and the Environment Bilthoven The Netherlands.; Boots AM; Department of Rheumatology and Clinical Immunology University Medical Center Groningen University of Groningen Groningen The Netherlands.; Hendriks M; Centre for Infectious Disease Control National Institute for Public Health and the Environment Bilthoven The Netherlands.; de Rond LG; Centre for Infectious Disease Control National Institute for Public Health and the Environment Bilthoven The Netherlands.; de Zeeuw-Brouwer ML; Centre for Infectious Disease Control National Institute for Public Health and the Environment Bilthoven The Netherlands.; Verschuren WM; Centre for Nutrition, Prevention and Health Services National Institute for Public Health and the Environment Bilthoven The Netherlands.; Julius Center for Health Sciences and Primary Care University Medical Center Utrecht The Netherlands.; Borghans JA; Center for Translational Immunology University Medical Center Utrecht Utrecht The Netherlands.; Buisman AM; Centre for Infectious Disease Control National Institute for Public Health and the Environment Bilthoven The Netherlands.; van Baarle D; Centre for Infectious Disease Control National Institute for Public Health and the Environment Bilthoven The Netherlands.; Center for Translational Immunology University Medical Center Utrecht Utrecht The Netherlands.
Source
Publisher: John Wiley & Sons Australia, Ltd. on behalf of Australasian Society for Immunology Inc Country of Publication: Australia NLM ID: 101638268 Publication Model: eCollection Cited Medium: Print ISSN: 2050-0068 (Print) Linking ISSN: 20500068 NLM ISO Abbreviation: Clin Transl Immunology Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2050-0068
Abstract
Objectives: Cytomegalovirus infection is thought to affect the immune system and to impact general health during ageing. Higher CMV-specific antibody levels in the elderly are generally assumed to reflect experienced viral reactivation during life. Furthermore, high levels of terminally differentiated and CMV-specific T cells are hallmarks of CMV infection, which are thought to expand over time, a process also referred to as memory inflation.
Methods: We studied CMV-specific antibody levels over ~ 27 years in 268 individuals (aged 60-89 years at study endpoint), and to link duration of CMV infection to T-cell numbers, CMV-specific T-cell functions, frailty and cardiovascular disease at study endpoint.
Results: In our study, 136/268 individuals were long-term CMV seropositive and 19 seroconverted during follow-up (seroconversion rate: 0.56%/year). CMV-specific antibody levels increased slightly over time. However, we did not find an association between duration of CMV infection and CMV-specific antibody levels at study endpoint. No clear association between duration of CMV infection and the size and function of the memory T-cell pool was observed. Elevated CMV-specific antibody levels were associated with the prevalence of cardiovascular disease but not with frailty. Age at CMV seroconversion was positively associated with CMV-specific antibody levels, memory CD4+ T-cell numbers and frailty.
Conclusion: Cytomegalovirus-specific memory T cells develop shortly after CMV seroconversion but do not seem to further increase over time. Age-related effects other than duration of CMV infection seem to contribute to CMV-induced changes in the immune system. Although CMV-specific immunity is not evidently linked to frailty, it tends to associate with higher prevalence of cardiovascular disease.
Competing Interests: The authors declare no conflict of interest.
(© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.)
Methods: We studied CMV-specific antibody levels over ~ 27 years in 268 individuals (aged 60-89 years at study endpoint), and to link duration of CMV infection to T-cell numbers, CMV-specific T-cell functions, frailty and cardiovascular disease at study endpoint.
Results: In our study, 136/268 individuals were long-term CMV seropositive and 19 seroconverted during follow-up (seroconversion rate: 0.56%/year). CMV-specific antibody levels increased slightly over time. However, we did not find an association between duration of CMV infection and CMV-specific antibody levels at study endpoint. No clear association between duration of CMV infection and the size and function of the memory T-cell pool was observed. Elevated CMV-specific antibody levels were associated with the prevalence of cardiovascular disease but not with frailty. Age at CMV seroconversion was positively associated with CMV-specific antibody levels, memory CD4
Conclusion: Cytomegalovirus-specific memory T cells develop shortly after CMV seroconversion but do not seem to further increase over time. Age-related effects other than duration of CMV infection seem to contribute to CMV-induced changes in the immune system. Although CMV-specific immunity is not evidently linked to frailty, it tends to associate with higher prevalence of cardiovascular disease.
Competing Interests: The authors declare no conflict of interest.
(© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.)