학술논문
Comparison of (18)F-fluorodeoxyglucose PET/CT findings with vascular endothelial growth factors and receptors in colorectal cancer.
Document Type
Academic Journal
Author
Kocael A; Department of Surgery, Cerrahpaşa Medical Faculty, University of İstanbul, İstanbul, Turkey.; Vatankulu B; Department of Nuclear Medicine, Cerrahpaşa Medical Faculty, University of İstanbul, Aksaray, İstanbul, Turkey. bvatankulu@gmail.com.; Şimşek O; Department of Surgery, Cerrahpaşa Medical Faculty, University of İstanbul, İstanbul, Turkey.; Cengiz M; Department of Internal Medicine, Cerrahpaşa Medical Faculty, University of İstanbul, İstanbul, Turkey.; Kemik A; Department of Biochemistry, Cerrahpaşa Medical Faculty, University of İstanbul, İstanbul, Turkey.; Kocael P; Department of Surgery, Cerrahpaşa Medical Faculty, University of İstanbul, İstanbul, Turkey.; Halaç M; Department of Nuclear Medicine, Cerrahpaşa Medical Faculty, University of İstanbul, Aksaray, İstanbul, Turkey.; Sönmezoğlu K; Department of Nuclear Medicine, Cerrahpaşa Medical Faculty, University of İstanbul, Aksaray, İstanbul, Turkey.; Ulualp K; Department of Surgery, Cerrahpaşa Medical Faculty, University of İstanbul, İstanbul, Turkey.
Source
Publisher: IOS Press Country of Publication: Netherlands NLM ID: 8409922 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0380 (Electronic) Linking ISSN: 10104283 NLM ISO Abbreviation: Tumour Biol Subsets: MEDLINE
Subject
Language
English
Abstract
The purpose of this study was to evaluate the association of (18)F-fluorodeoxyglucose (FDG)-PET/CT findings with the vascular endothelial growth factor (VEGF) family and its receptor (VEGFR) levels in metastatic and nonmetastatic colorectal cancer (CRC). Fluorine-18 FDG-PET/CT scans were performed for initial staging and restaging of patients with CRC. FDG-PET/CT findings of tumor (such as the presence of a primary tumor, the lymphatic or distance metastases, and the maximum standardized uptake value (SUVmax) of the primary tumor), serum VEGF A-C-D-E levels, and serum VEGF receptor 1-2-3 levels were analyzed. A total of 63 patients were included into the study (35 males, mean age 61.3 ± 11.9 years). Patients were divided into two groups, based on positive and negative PET/CT findings. Patients were also categorized according to the presence of metastasis. All evaluated parameters were significantly higher in the PET/CT-positive group than the PET/CT-negative group (p < 0.001). All those parameters were also positively correlated with each other. The highest correlation for SUVmax of primary tumor was found with VEGFR-3 (p < 0.001, r = 0.665). Patients with metastases had high levels of VEGF-D, VEGF-A, VEGF-C, VEGF-E, and VEGFR-3 than those without metastases. These parameters had better specificity and sensitivity values than the SUVmax of the primary tumor for detection of metastases. However, VEGF-D was the best indicator of metastasis in all of those parameters (VEGF-D vs SUVmax; sensitivity 100 vs 100 %; specificity 76 vs 76 %; AUC 0.903 vs 0.835; p < 0.001, respectively). Vascular endothelial growth factor family and its receptors were significantly higher in metastatic CRC patients. VEGF-D was the best indicator of metastasis than all VEGF family, VEGFR-3, and primary tumor SUVmax. VEGF family (A-C-D-E) and VEGFR-3 may help to determine the prognosis and management of CRC.