학술논문
Disaggregation and fibrillation during sol-gel transition of alginate hydrogels.
Document Type
Academic Journal
Author
Nakada M; Toray Research Center, Inc., 2-11 Sonoyama 3-chome, Otsu 520-8567, Shiga, Japan. Electronic address: masaru.nakada.n3@trc.toray.; Ishida H; Toray Research Center, Inc., 2-11 Sonoyama 3-chome, Otsu 520-8567, Shiga, Japan.; Uchiyama H; Toray Research Center, Inc., 2-11 Sonoyama 3-chome, Otsu 520-8567, Shiga, Japan.; Ota R; Toray Research Center, Inc., 2-11 Sonoyama 3-chome, Otsu 520-8567, Shiga, Japan.; Ogura T; Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, Higashi, Tsukuba 305-8566, Ibaraki, Japan.; Namiki Y; KIMICA Corporation, 2-1-1 Yaesu, Chuo-ku, 104-0028 Tokyo, Japan.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Subject
Language
English
Abstract
The rheological and morphological characteristics of Ca-crosslinked alginate hydrogels with two different M/G ratios, α-L-guluronate (G)-rich and β-D-mannuronate (M)-rich, each with one alginic acid concentration, were investigated. It was found that the stiffness and elasticity of alginate hydrogels are derived from the thickness and density of the fibril network structures. In aqueous alginate solution, ball-like aggregates of alginates are present. Time-resolved small-angle X-ray scattering and time-domain nuclear magnetic resonance measurements suggest that the disaggregation of alginate aggregates and loose fibrillation occur in the early stage of the sol-gel transition. After these induction stage, direct gelation is finally caused by the formation of the egg-box junction. G-rich alginate hydrogel has a higher stiffness and a thicker and denser fibril network structure than M-rich alginate hydrogel. The former also exhibits faster and more significant changes in physical properties during the sol-gel transition.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)