학술논문
Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum.
Document Type
Academic Journal
Author
Ferini-Strambi L; Sleep Disorders Center, Division of Neuroscience, Università Vita-Salute San Raffaele, Milan, Italy. ferinistrambi.luigi@hsr.it.; Liguori C; Sleep Medicine Center, University of Rome Tor Vergata, Rome, Italy.; Lucey BP; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.; Mander BA; Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.; Spira AP; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Videnovic A; Department of Neurology, Division of Sleep Medicine, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.; Baumann C; Department of Neurology, University Hospital Zurich, Zurich, Switzerland.; Franco O; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.; Fernandes M; Sleep Medicine Center, University of Rome Tor Vergata, Rome, Italy.; Gnarra O; Department of Neurology, University of Bern, Bern, Switzerland.; Krack P; Department of Neurology, University of Bern, Bern, Switzerland.; Manconi M; Sleep Medicine Unit, Faculty of Biomedical Sciences, Neurocenter of the Southern Switzerland, Regional Hospital of Lugano, Università Della Svizzera Italiana, Lugano, Switzerland.; Noain D; Department of Neurology, University of Bern, Bern, Switzerland.; Saxena S; Department of Neurology, University of Bern, Bern, Switzerland.; Kallweit U; Clinical Sleep and Neuroimmunology, University Witten/Herdecke, Witten, Germany.; Randerath W; Institute Für Pneumologie an der Universität Zu Köln, Cologne, Germany.; Trenkwalder C; Department of Neurosurgery, Paracelsus-Elena Klinik, University Medical Center, KasselGoettingen, Germany.; Rosenzweig I; Sleep and Brain Plasticity Centre, Department of Neuroimaging, King's College London, London, UK.; Iranzo A; Sleep Center, Neurology Service, Hospital Clinic de Barcelona, Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.; Bradicich M; Department of Pulmonology and Sleep Disorders Centre, University Hospital Zurich, Zurich, Switzerland.; Bassetti C; Department of Neurology, University of Bern, Bern, Switzerland.
Source
Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE
Subject
Language
English
Abstract
Sleep abnormalities may represent an independent risk factor for neurodegeneration. An international expert group convened in 2021 to discuss the state-of-the-science in this domain. The present article summarizes the presentations and discussions concerning the importance of a strategy for studying sleep- and circadian-related interventions for early detection and prevention of neurodegenerative diseases. An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years; discussed the current challenges in the field of relationships among sleep, sleep disorders, and neurodegeneration; and identified future priorities. Sleep efficiency and slow wave activity during non-rapid eye movement (NREM) sleep are decreased in cognitively normal middle-aged and older adults with Alzheimer's disease (AD) pathology. Sleep deprivation increases amyloid-β (Aβ) concentrations in the interstitial fluid of experimental animal models and in cerebrospinal fluid in humans, while increased sleep decreases Aβ. Obstructive sleep apnea (OSA) is a risk factor for dementia. Studies indicate that positive airway pressure (PAP) treatment should be started in patients with mild cognitive impairment or AD and comorbid OSA. Identification of other measures of nocturnal hypoxia and sleep fragmentation could better clarify the role of OSA as a risk factor for neurodegeneration. Concerning REM sleep behavior disorder (RBD), it will be crucial to identify the subset of RBD patients who will convert to a specific neurodegenerative disorder. Circadian sleep-wake rhythm disorders (CSWRD) are strong predictors of caregiver stress and institutionalization, but the absence of recommendations or consensus statements must be considered. Future priorities include to develop and validate existing and novel comprehensive assessments of CSWRD in patients with/at risk for dementia. Strategies for studying sleep-circadian-related interventions for early detection/prevention of neurodegenerative diseases are required. CSWRD evaluation may help to identify additional biomarkers for phenotyping and personalizing treatment of neurodegeneration.
(© 2023. Fondazione Società Italiana di Neurologia.)
(© 2023. Fondazione Società Italiana di Neurologia.)