학술논문
Association between preoperative diastolic dysfunction and early allograft dysfunction after orthotopic liver transplantation: An observational study.
Document Type
Academic Journal
Author
Vetrugno L; Department of Medical, Oral, and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy.; Cherchi V; General Surgery Clinic and Liver Transplant Center, University-Hospital of Udine, Udine, Italy.; Zanini V; Department of Medicine, University of Udine, Udine, Italy.; Cotrozzi S; Department of Medicine, University of Udine, Udine, Italy.; Ventin M; Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.; Terrosu G; General Surgery Clinic and Liver Transplant Center, University-Hospital of Udine, Udine, Italy.; Baccarani U; General Surgery Clinic and Liver Transplant Center, University-Hospital of Udine, Udine, Italy.; Bove T; Department of Medicine, University of Udine, Udine, Italy.
Source
Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8511187 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8175 (Electronic) Linking ISSN: 07422822 NLM ISO Abbreviation: Echocardiography Subsets: MEDLINE
Subject
Language
English
Abstract
Objectives: To investigate the association between the grade of diastolic dysfunction (DD) and the occurrence of early allograft dysfunction (EAD) in liver transplant patients following the new 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging (ASE/EACVI) guidelines.
Methods: From January 2015 to December 2019, we retrospectively analyzed 83 patients who underwent orthotopic liver transplantation (OLTx) and their susceptibility to develop EAD according to the grade of preoperative DD. EAD was defined according to the criteria proposed by Olfhoff et al.; DD was defined with four parameters: E/A, e/e', Left Atrium volume, and Tricuspid Regurgitation velocity.
Results: According to the ASE/EACVI guidelines grade II DD was detected in 20 patients (24.1%) undergoing OLTx. A statistically significant association was found between grade II DD and the occurrence of EAD (p-value < 0.003). The Kaplan-Meier analysis failed to find any significant difference between the survival probability, nevertheless at the end of a 90-day follow-up period, mortality showed a different trend in classes with more severe diastolic dysfunction.
Conclusion: According to the ASE/EACVI guidelines from 2016, patients with grade II DD seem to have a higher propensity to develop early allograft dysfunction EAD after OLTx. Our study advises a need for an urgent prospective multicenter study to elucidate the long-term outcomes of liver transplants patients with diastolic dysfunction.
(© 2022 Wiley Periodicals LLC.)
Methods: From January 2015 to December 2019, we retrospectively analyzed 83 patients who underwent orthotopic liver transplantation (OLTx) and their susceptibility to develop EAD according to the grade of preoperative DD. EAD was defined according to the criteria proposed by Olfhoff et al.; DD was defined with four parameters: E/A, e/e', Left Atrium volume, and Tricuspid Regurgitation velocity.
Results: According to the ASE/EACVI guidelines grade II DD was detected in 20 patients (24.1%) undergoing OLTx. A statistically significant association was found between grade II DD and the occurrence of EAD (p-value < 0.003). The Kaplan-Meier analysis failed to find any significant difference between the survival probability, nevertheless at the end of a 90-day follow-up period, mortality showed a different trend in classes with more severe diastolic dysfunction.
Conclusion: According to the ASE/EACVI guidelines from 2016, patients with grade II DD seem to have a higher propensity to develop early allograft dysfunction EAD after OLTx. Our study advises a need for an urgent prospective multicenter study to elucidate the long-term outcomes of liver transplants patients with diastolic dysfunction.
(© 2022 Wiley Periodicals LLC.)