학술논문
Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome.
Document Type
Academic Journal
Author
Torre D; Section of Pediatric Infectious Diseases, Regional Hospital, Viale Borri 57, 21100 Varese, Italy. eiwle@tin.it; Tambini R; Manfredi M; Mangani V; Livi P; Maldifassi V; Chiaranda M; Campi P; Speranza F
Source
Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print Cited Medium: Print ISSN: 0163-4453 (Print) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE
Subject
Language
English
ISSN
0163-4453
Abstract
Objectives: Granulocyte-macrophage colony stimulating factor (GM-CSF) is a key regulator cytokine that modulates the proliferation and maturation of polymorphonuclear and mononuclear progenitors. This study was designed to investigate and clarify the role of GM-CSF in 52 critically ill patients with systemic inflammatory response syndrome (SIRS).
Methods: Serum levels of GM-CSF were detected by an immunoenzyme assay.
Results: Our results clearly show that the serum concentrations of GM-CSF were significantly elevated in patients with infectious and noninfectious SIRS (33.2+/-45.7pg/ml, controls: 17.2+/-9.8pg/ml; p=0.0303). In addition, GM-CSF levels significantly decreased in patients with SIRS, particularly in patients with infectious SIRS, 5 and 7 days later. There was a clear tendency toward higher levels of GM-CSF in patients with poor, as compared with those having a good outcome of the disease.
Conclusion: These results show that GM-CSF may play an important role in patients with infectious and noninfectious SIRS, and that GM-CSF levels progressively and significantly decrease in patients with infectious SIRS.
Methods: Serum levels of GM-CSF were detected by an immunoenzyme assay.
Results: Our results clearly show that the serum concentrations of GM-CSF were significantly elevated in patients with infectious and noninfectious SIRS (33.2+/-45.7pg/ml, controls: 17.2+/-9.8pg/ml; p=0.0303). In addition, GM-CSF levels significantly decreased in patients with SIRS, particularly in patients with infectious SIRS, 5 and 7 days later. There was a clear tendency toward higher levels of GM-CSF in patients with poor, as compared with those having a good outcome of the disease.
Conclusion: These results show that GM-CSF may play an important role in patients with infectious and noninfectious SIRS, and that GM-CSF levels progressively and significantly decrease in patients with infectious SIRS.