학술논문
Association of variabilities in body mass index and waist circumference with newly achieved remission of metabolic dysfunction-associated fatty liver disease.
Document Type
Academic Journal
Author
Sogabe M; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan; Department of Internal Medicine, Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers, 2233 Kawanoe-cho, Shikokuchuo City, Ehime, 799-0193, Japan. Electronic address: sogabe.masahiro@tokushima-u.ac.jp.; Okahis T; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan; Department of Internal Medicine, Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers, 2233 Kawanoe-cho, Shikokuchuo City, Ehime, 799-0193, Japan.; Kagawa M; Department of Internal Medicine, Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers, 2233 Kawanoe-cho, Shikokuchuo City, Ehime, 799-0193, Japan.; Sei M; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan; Department of Internal Medicine, Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers, 2233 Kawanoe-cho, Shikokuchuo City, Ehime, 799-0193, Japan.; Ueda H; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan; Department of Internal Medicine, Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers, 2233 Kawanoe-cho, Shikokuchuo City, Ehime, 799-0193, Japan.; Yokoyama R; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.; Kagemoto K; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.; Tanaka H; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.; Kida Y; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.; Nakamura F; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.; Tomonari T; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.; Okamoto K; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.; Miyamoto H; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.; Sato Y; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.; Nakasono M; Department of Internal Medicine, Tsurugi Municipal Handa Hospital, 234-1Nakayabu, Handaaza, Tsurugi-cho, Mimagun, Tokushima, 779-4401, Japan.; Takayama T; Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.
Source
Publisher: Elsevier Ltd Country of Publication: Netherlands NLM ID: 101462250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0334 (Electronic) Linking ISSN: 18714021 NLM ISO Abbreviation: Diabetes Metab Syndr Subsets: MEDLINE
Subject
Language
English
Abstract
Aims: Although body weight reduction is recommended to ameliorate nonalcoholic fatty liver disease, the effects of body mass index (BMI) and waist circumference (WC) variability on newly achieved remission of metabolic dysfunction-associated fatty liver disease (MAFLD) remain unclear. We aimed to investigate the longitudinal association between BMI and WC variabilities and newly achieved MAFLD remission in both sexes.
Methods: Among 26,952 patients, 1823 with MAFLD diagnosed by ultrasonography and with >2 health checkups over >2 years from April 2014 to March 2021 were included in this observational cohort study. A generalized estimation equation model analyzed the association between BMI and WC and newly achieved MAFLD remission according to repeated measures at baseline and the most recent stage.
Results: Rates of MAFLD remission in male and female patients were 7.4 % and 6.0 %, respectively. Regarding decreased BMI variability, newly achieved MAFLD remission prevalence among the subgroups differed significantly between sexes (p < 0.001). In male patients, a decrease in BMI variability of ≥1.5 kg/m2 and WC variability of ≥4.2 cm had adjusted odds ratios (ORs) of 5.215 and 2.820, respectively, for newly achieved MAFLD remission. Among female patients, regular exercise and breakfast consumption were accelerating factors for newly achieved MAFLD remission. Non-invasive liver fibrosis scores significantly differed between MAFLD and newly achieved MAFLD remission, including in the subgroups (p < 0.01 and p < 0.001, respectively).
Conclusions: Reducing BMI and WC variabilities in male patients and improving lifestyle habits in female patients may accelerate MAFLD remission.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved.)
Methods: Among 26,952 patients, 1823 with MAFLD diagnosed by ultrasonography and with >2 health checkups over >2 years from April 2014 to March 2021 were included in this observational cohort study. A generalized estimation equation model analyzed the association between BMI and WC and newly achieved MAFLD remission according to repeated measures at baseline and the most recent stage.
Results: Rates of MAFLD remission in male and female patients were 7.4 % and 6.0 %, respectively. Regarding decreased BMI variability, newly achieved MAFLD remission prevalence among the subgroups differed significantly between sexes (p < 0.001). In male patients, a decrease in BMI variability of ≥1.5 kg/m
Conclusions: Reducing BMI and WC variabilities in male patients and improving lifestyle habits in female patients may accelerate MAFLD remission.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved.)