학술논문
Microscale visualization of cellular features in adult macaque visual cortex.
Document Type
Author
Balaram P; Takasaki K; Hellevik A; Tandukar J; Turschak E; MacLennan B; Ouellette N; Torres R; Laughland C; Gliko O; Seshamani S; Perlman E; Taormina M; Peterson E; Juneau Z; Potekhina L; Glaser A; Chandrashekar J; Logsdon M; Cao K; Dylla C; Hatanaka G; Chatterjee S; Ting J; Vumbaco D; Waters J; Bair W; Tsao D; Gao R; Reid C
Source
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Expansion microscopy and light sheet imaging enable fine-scale resolution of intracellular features that comprise neural circuits. Most current techniques visualize sparsely distributed features across whole brains or densely distributed features within individual brain regions. Here, we visualize dense distributions of immunolabeled proteins across early visual cortical areas in adult macaque monkeys. This process may be combined with multiphoton or magnetic resonance imaging to produce multimodal atlases in large, gyrencephalic brains.