학술논문
Emerging role of nutritional short-chain fatty acids (SCFAs) against cancer via modulation of hematopoiesis.
Document Type
Academic Journal
Author
Thiruvengadam M; Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul, Republic of Korea.; Subramanian U; Translational Research Platform for Veterinary Biologicals, Tamil Nadu Veterinary and Animal Sciences University, Chennai, India.; Venkidasamy B; Department of Biotechnology, Sri Shakthi Institute of Engineering and Technology, Coimbatore, India.; Thirupathi P; Translational Research Platform for Veterinary Biologicals, Tamil Nadu Veterinary and Animal Sciences University, Chennai, India.; Samynathan R; R&D Division, Alchem Diagnostics, Coimbatore, India.; Shariati MA; Department of Technology of Food Products, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), Moscow, Russian Federation.; Rebezov M; V M Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russian Federation.; Prokhorov General Physics Institute of the Russian Academy of Science, Moscow, Russian Federation.; Chung IM; Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul, Republic of Korea.; Rengasamy KRR; Green Biotechnologies Research Centre of Excellence, University of Limpopo, Mankweng, South Africa.
Source
Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 8914818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-7852 (Electronic) Linking ISSN: 10408398 NLM ISO Abbreviation: Crit Rev Food Sci Nutr Subsets: MEDLINE
Subject
Language
English
Abstract
The understanding of gut microbiota has emerged as a significant frontier in development of strategies to maintain normal human body's homeostasis and preventing the disease development over the last decade. The composition of the gut microbiota influences the clinical benefit of immune checkpoints in patients with advanced cancer, but the mechanisms underlying this relationship are unclear. Cancer is among the leading causes of mortality worldwide. So far, there is no universal treatment for cancer and despite significant advances, a lot of improvement on cancer therapy is required. Owing to its role in preserving the host's health and maintaining cellular integrity, the human gut microbiome has recently drawn a lot of interest as a target for cancer treatment. Dietary fiber is fermented by the gut microbiota to generate short-chain fatty acids (SCFAs), such as acetate, butyrate, and propionate, which are physiologically active metabolites. SCFAs can modulate the pathophysiology of the tumor environment through various critical signaling pathways. In addition, SCFAs can bind to carcinogens and other toxic chemicals, thus facilitating their biotransformation and elimination through different excretory mechanisms. This review discusses the mechanisms of action of short-chain fatty acids in modulating hematopoiesis of various immune system cells and the resultant beneficial anti-cancer effects. It also provides future perspectives on cancer therapy.