학술논문

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence.
Document Type
Academic Journal
Author
Choudhary P; Research Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland. Priyanka.Choudhary@oulu.fi.; Monasso GS; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Karhunen V; Research Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.; Research Unit of Mathematical Sciences, Faculty of Science, University of Oulu, Oulu, Finland.; Ronkainen J; Research Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.; Mancano G; Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.; Bristol Medical School Population Health Sciences, University of Bristol, Bristol, UK.; Howe CG; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.; Niu Z; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Zeng X; Glotech, Inc., Rockville, MD, 20850, USA.; Guan W; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.; Dou J; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Feinberg JI; Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MA, USA.; Mordaunt C; Department of Medical Micriobiology and Immunology, University of California Davis, Davis, CA, USA.; Pesce G; Epidemiology of Allergic and Respiratory Diseases (EPAR) team, Faculté de Médecine Saint-Antoine, Institute Pierre Louis d'Epidemiologie et Sante Publique (IPLESP), Sorbonne Université and INSERM, Paris, France.; Paris-Saclay University, Paris-South University, UVSQ, Center for Research in Epidemiology and Population Health (CESP), INSERM, Villejuif, France.; Baïz N; Institute Desbrest of Epidemiology and Public Health, University of Montpellier and INSERM, Montpellier, France.; Alfano R; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.; Martens DS; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.; Wang C; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.; Isaevska E; Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Torino, Italy.; Keikkala E; Department of Obstetrics and Gynaecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.; Finnish Institute for Health and Welfare, Population Health Unit, Public Health and Welfare, Helsinki and Oulu, Finland.; Mustaniemi S; Department of Obstetrics and Gynaecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.; Finnish Institute for Health and Welfare, Population Health Unit, Public Health and Welfare, Helsinki and Oulu, Finland.; Thio CHL; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Fraszczyk E; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Tobi EW; Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, 3000 CA, Rotterdam, the Netherlands.; Starling AP; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Cosin-Tomas M; ISGlobal (Barcelona Institute for Global Health), Barcelona Biomedical Research Park (PRBB), Doctor Aiguader, 88, 08003, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Urquiza J; ISGlobal (Barcelona Institute for Global Health), Barcelona Biomedical Research Park (PRBB), Doctor Aiguader, 88, 08003, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Röder S; Department for Environmental Immunology, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.; Hoang TT; Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.; Page C; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; Oslo Centre for Biostatistics and Epidemiology, Section for Research Support, Oslo University Hospital, Oslo, Norway.; Jima DD; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, USA.; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, 27606, USA.; House JS; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, USA.; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC, 27709, USA.; Maguire RL; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.; Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, 27701, USA.; Ott R; Institute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.; Forschergruppe Diabetes eV, Neuherberg, Germany.; Pawlow X; Institute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.; Forschergruppe Diabetes eV, Neuherberg, Germany.; Sirignano L; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Zillich L; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Malmberg A; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Rauschert S; Telethon Kids Institute, Perth, WA, Australia.; Melton P; Menzies Institute of Medical Research, University of Tasmania, Hobart, TAS, Australia.; University of Western Australia, School of Population and Global Health, Perth, WA, Australia.; Gong T; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Karlsson R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Fore R; Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Perng W; Department of Epidemiology and the Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Laubach ZM; Department of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA.; Czamara D; Department Genes and Environment, Max Planck Institute for Psychiatry, Kraepelinstrasse 2+10, 80804, Munich, Germany.; Sharp G; Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.; Bristol Medical School Population Health Sciences, University of Bristol, Bristol, UK.; School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.; Breton CV; Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Schisterman E; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Yeung E; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, 20817, USA.; Mumford SL; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, 20817, USA.; Fallin MD; Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MA, USA.; LaSalle JM; Department of Medical Micriobiology and Immunology, University of California Davis, Davis, CA, USA.; Schmidt RJ; Department of Public Health Sciences, School of Medicine, University of California Davis (UC Davis), Davis, CA, USA.; Bakulski KM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Annesi-Maesano I; Institute Desbrest of Epidemiology and Public Health, University of Montpellier and INSERM, Montpellier, France.; Heude B; Université de Paris Cité, Inserm, INRAE, Centre of Research in Epidemiology and StatisticS (CRESS), F-75004, Paris, France.; Nawrot TS; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.; Plusquin M; Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.; Ghantous A; Epigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.; Herceg Z; Epigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.; Nisticò L; Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena, Rome, Italy.; Vafeiadi M; Department of Social Medicine, School of Medicine, University of Crete, Heraklion, Crete, Greece.; Kogevinas M; Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Centro de Investigación Biomédicaen Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Vääräsmäki M; Department of Obstetrics and Gynaecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.; Finnish Institute for Health and Welfare, Population Health Unit, Public Health and Welfare, Helsinki and Oulu, Finland.; Kajantie E; Finnish Institute for Health and Welfare, Population Health Unit, Public Health and Welfare, Helsinki and Oulu, Finland.; Clinical Medicine Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Corpeleijn E; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Steegers-Theunissen RPM; Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, 3000 CA, Rotterdam, the Netherlands.; Yang IV; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.; Dabelea D; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Fossati S; ISGlobal (Barcelona Institute for Global Health), Barcelona Biomedical Research Park (PRBB), Doctor Aiguader, 88, 08003, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Zenclussen AC; Department for Environmental Immunology, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.; Herberth G; Department for Environmental Immunology, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.; Magnus M; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; Håberg SE; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; London SJ; Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.; Munthe-Kaas MC; Department of Pediatrics, Oncology and Hematology, Oslo University Hospital, Oslo, Norway.; Norwegian Institute of Public Health, Oslo, Norway.; Murphy SK; Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, 27701, USA.; Hoyo C; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, USA.; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.; Ziegler AG; Institute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.; Forschergruppe Diabetes eV, Neuherberg, Germany.; Technical University Munich, School of Medicine, Forschergruppe Diabetes at Klinikum rechts der Isar, Munich, Germany.; Hummel S; Institute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.; Forschergruppe Diabetes eV, Neuherberg, Germany.; Technical University Munich, School of Medicine, Forschergruppe Diabetes at Klinikum rechts der Isar, Munich, Germany.; Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Innovative Psychiatric and Psychotherapeutic Research, Biobank, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Streit F; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Frank J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Räikkönen K; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Lahti J; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Huang RC; Telethon Kids Institute, Perth, WA, Australia.; Edith Cowan University, School of Medicine and Health Sciences, Joondalup, WA, Australia.; Almqvist C; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.; Hivert MF; Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Jaddoe VWV; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Järvelin MR; Research Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.; Kantomaa M; Research Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.; Felix JF; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Sebert S; Research Unit of Population Health, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.
Source
Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Subject
Language
English
Abstract
Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B 12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.
(© 2023. The Author(s).)