학술논문
Synthetic Antigen-Conjugated DNA Systems for Antibody Detection and Characterization.
Document Type
Academic Journal
Author
Ranallo S; Department of Chemical Science and Technologies, University of Rome Tor Vergata, 00133, Rome, Italy.; Bracaglia S; Department of Chemical Science and Technologies, University of Rome Tor Vergata, 00133, Rome, Italy.; Sorrentino D; Department of Chemical Science and Technologies, University of Rome Tor Vergata, 00133, Rome, Italy.; Ricci F; Department of Chemical Science and Technologies, University of Rome Tor Vergata, 00133, Rome, Italy.
Source
Publisher: American Chemical Society Country of Publication: United States NLM ID: 101669031 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-3694 (Electronic) Linking ISSN: 23793694 NLM ISO Abbreviation: ACS Sens Subsets: MEDLINE
Subject
Language
English
Abstract
Antibodies are among the most relevant biomolecular targets for diagnostic and clinical applications. In this Perspective, we provide a critical overview of recent research efforts focused on the development and characterization of devices, switches, and reactions based on the use of synthetic antigen-conjugated DNA strands designed to be responsive to specific antibodies. These systems can find applications in sensing, drug-delivery, and antibody-antigen binding characterization. The examples described here demonstrate how the programmability and chemical versatility of synthetic nucleic acids can be used to create innovative analytical tools and target-responsive systems with promising potentials.