학술논문
Personalization matters: the effect of sex in multivitamin-multimineral-based cancer prevention.
Document Type
Academic Journal
Author
Šelb J; The NU B.V., J.H. Oortweg 21, 2333CH, Leiden, The Netherlands. julij.selb@thenu.com.; University Clinic of Respiratory and Allergic Diseases Golnik, Golnik 36, 4204, Golnik, Slovenia. julij.selb@thenu.com.; Cvetko F; The NU B.V., J.H. Oortweg 21, 2333CH, Leiden, The Netherlands.; Deutsch L; The NU B.V., J.H. Oortweg 21, 2333CH, Leiden, The Netherlands.; Bedrač L; The NU B.V., J.H. Oortweg 21, 2333CH, Leiden, The Netherlands.; Kuščer E; The NU B.V., J.H. Oortweg 21, 2333CH, Leiden, The Netherlands.; Maier AB; The NU B.V., J.H. Oortweg 21, 2333CH, Leiden, The Netherlands.; Department of Human Movement Sciences, @AgeAmsterdam Amsterdam Movement Sciences Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Republic of Singapore.
Source
Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Subject
Language
English
Abstract
The prevention of non-communicable diseases like cancer contributes to healthy aging. Dietary supplements might support such prevention; their effect likely depends on the personal characteristics of the individuals receiving them. To evaluate the influence of sex on reducing cancer incidence with multivitamin-multimineral (MVM) supplementation, sex-specific results of the efficacy of MVM supplementation for cancer prevention were collected and meta-analyzed (using fixed effect (FE) and random effect (RE) models). Three trials included in the "US Preventive Services Task Force Recommendation Statement Report regarding Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer" were used, namely, COSMOS, SU.VI.MAX, and PHS2. A total of 28,558 men and 20,542 women were included. Multivitamin-multimineral supplementation significantly reduced cancer incidence in the entire population (HR 0.93 [95% CI, 0.88-0.99], FE and RE); sex-specific meta-analysis showed beneficial effects of supplementation in men (HR 0.91 [95% CI, 0.85-0.97] (FE)/0.88 [95% CI, 0.77-1.01] (RE)); however, there was no effect in women (HR 1.00 [95% CI, 0.88-1.14], FR and RE); (P difference = 0.17). Sex could influence the effect of MVM supplementation in reducing cancer incidence, with supplementation being effective only in male individuals. These results might be informative for future research and public health policy makers.
(© 2023. The Author(s).)
(© 2023. The Author(s).)