학술논문
Gold Nanoparticles Capped with a Novel Titanium(IV)-Containing Polyoxomolybdate Cluster: Selective and Enhanced Bactericidal Effect Against Escherichia coli.
Document Type
Academic Journal
Author
Paesa M; Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza, 50009, Spain.; Department of Chemical Engineering, University of Zaragoza, Campus Río Ebro-Edificio I+D, C/Poeta Mariano Esquillor S/N, Zaragoza, 50018, Spain.; Almazán F; Instituto de Materiales Avanzados y Matemáticas (INAMAT2), Universidad Pública de Navarra (UPNA), Edificio Jerónimo de Ayanz, Campus de Arrosadia, Pamplona, 31006, Spain.; Departamento de Ciencias, Universidad Pública de Navarra (UPNA), Edificio los Acebos, Campus de Arrosadia, Pamplona, 31006, Spain.; Yus C; Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza, 50009, Spain.; Department of Chemical Engineering, University of Zaragoza, Campus Río Ebro-Edificio I+D, C/Poeta Mariano Esquillor S/N, Zaragoza, 50018, Spain.; Sebastián V; Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza, 50009, Spain.; Department of Chemical Engineering, University of Zaragoza, Campus Río Ebro-Edificio I+D, C/Poeta Mariano Esquillor S/N, Zaragoza, 50018, Spain.; Aragon Health Research Institute (IIS Aragon), Zaragoza, 50009, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Madrid, 28029, Spain.; Arruebo M; Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza, 50009, Spain.; Department of Chemical Engineering, University of Zaragoza, Campus Río Ebro-Edificio I+D, C/Poeta Mariano Esquillor S/N, Zaragoza, 50018, Spain.; Aragon Health Research Institute (IIS Aragon), Zaragoza, 50009, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Madrid, 28029, Spain.; Gandía LM; Instituto de Materiales Avanzados y Matemáticas (INAMAT2), Universidad Pública de Navarra (UPNA), Edificio Jerónimo de Ayanz, Campus de Arrosadia, Pamplona, 31006, Spain.; Departamento de Ciencias, Universidad Pública de Navarra (UPNA), Edificio los Acebos, Campus de Arrosadia, Pamplona, 31006, Spain.; Reinoso S; Instituto de Materiales Avanzados y Matemáticas (INAMAT2), Universidad Pública de Navarra (UPNA), Edificio Jerónimo de Ayanz, Campus de Arrosadia, Pamplona, 31006, Spain.; Departamento de Ciencias, Universidad Pública de Navarra (UPNA), Edificio los Acebos, Campus de Arrosadia, Pamplona, 31006, Spain.; Pellejero I; Instituto de Materiales Avanzados y Matemáticas (INAMAT2), Universidad Pública de Navarra (UPNA), Edificio Jerónimo de Ayanz, Campus de Arrosadia, Pamplona, 31006, Spain.; Departamento de Ciencias, Universidad Pública de Navarra (UPNA), Edificio los Acebos, Campus de Arrosadia, Pamplona, 31006, Spain.; Mendoza G; Aragon Health Research Institute (IIS Aragon), Zaragoza, 50009, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Madrid, 28029, Spain.
Source
Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE
Subject
Language
English
Abstract
Bacterial infections are a public health threat of increasing concern in medical care systems; hence, the search for novel strategies to lower the use of antibiotics and their harmful effects becomes imperative. Herein, the antimicrobial performance of four polyoxometalate (POM)-stabilized gold nanoparticles (Au@POM) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as Gram-negative and Gram-positive bacteria models, respectively, is studied. The bactericidal studies performed, both in planktonic and sessile forms, evidence the antimicrobial potential of these hybrid nanostructures with selectivity toward Gram-negative species. In particular, the Au@GeMoTi composite with the novel [Ti 2 (HGeMo 7 O 28 ) 2 ] 10- POM capping ligand exhibits outstanding bactericidal efficiency with a minimum inhibitory concentration of just 3.12 µm for the E. coli strain, thus outperforming the other three Au@POM counterparts. GeMoTi represents the fourth example of a water-soluble Ti IV -containing polyoxomolybdate, and among them, the first sandwich-type structure having heteroatoms in high-oxidation state. The evaluation of the bactericidal mechanisms of action points to the cell membrane hyperpolarization, disruption, and subsequent nucleotide leakage and the low cytotoxicity exerted on five different cell lines at antimicrobial doses demonstrates the antibiotic-like character. These studies highlight the successful design and development of a new POM-based nanomaterial able to eradicate Gram-negative bacteria without damaging mammalian cells.
(© 2023 The Authors. Small published by Wiley-VCH GmbH.)
(© 2023 The Authors. Small published by Wiley-VCH GmbH.)