학술논문
Does α-lipoic acid therapeutically effective against experimentally induced-acute pulpitis in rats?
Document Type
Academic Journal
Author
Kermeoğlu F; Department of Endodontics, Faculty of Dentistry, Near East University, Nicosia, North Cyprus, Turkey.; Sayıner S; Department of Biochemistry, Faculty of Veterinary Medicine, Near East University, Nicosia, North Cyprus, Turkey.; Şehirli AÖ; Departments of Pharmacology, Faculty of Dentistry, Near East University, Nicosia, North Cyprus, Turkey.; Savtekin G; Department of Oral and Maxillofacial Surgery, School of Dental Sciences, Ada Kent University, Morphou, Cyprus.; Aksoy U; Department of Endodontics, Faculty of Dentistry, Near East University, Nicosia, North Cyprus, Turkey.
Source
Publisher: Wiley-Blackwell Publishing Asia Country of Publication: Australia NLM ID: 100888004 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4477 (Electronic) Linking ISSN: 13291947 NLM ISO Abbreviation: Aust Endod J
Subject
Language
English
Abstract
The purpose of the study was to investigate the therapeutic effects of α-lipoic acid (ALA) on an induced-acute pulpitis model in rats. Twenty-four Wistar albino rats were randomly divided into three groups: control, induced-acute pulpitis (PULP) and PULP + ALA groups. In the PULP and PULP + ALA groups, the crowns of the maxillary left incisors were removed horizontally. All exposed pulp tissues were treated with 5 µL LPS solution. In the PULP + ALA group, the rats were treated intraperitoneally with a single dose of ALA (100 mg/kg). The rats were sacrificed 24 h after pulp injury, and the trunk blood and pulp samples were collected and then determined using ELISA assay kits. TNF-α, IL-1β, MMP-1 and MMP-2 levels in the serum and pulp tissues were considerably higher in the PULP group than the control group (p < 0.01-0.001). In the PULP + ALA group, TNF-α, IL-1β, MMP-1 and MMP-2 levels in the serum and pulp tissues decreased significantly compared to the PULP group (p < 0.05-0.001). ALA decreases pro-inflammatory mediators and proteolytic enzymes, which might relieve acute inflammation.
(© 2022 Australian Society of Endodontology Inc.)
(© 2022 Australian Society of Endodontology Inc.)