학술논문
Relation of serum BDNF to major depression and exploration of mechanistic roles of serum BDNF in a study of vitamin D3 and omega-3 supplements for late-life depression prevention.
Document Type
Academic Journal
Author
Vyas CM; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: cvyas@partners.org.; Mischoulon D; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Chang G; Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Boston, MA, USA.; Reynolds CF 3rd; Department of Psychiatry, UPMC and University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Cook NR; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Weinberg A; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Copeland T; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Bubes V; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Bradwin G; Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.; Lee IM; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Buring JE; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Mora S; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Rifai N; Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.; Manson JE; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Okereke OI; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Source
Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE
Subject
Language
English
Abstract
This study: 1) examined cross-sectional and longitudinal relations of serum brain-derived neurotrophic factor (BDNF) to late-life depression (LLD); 2) tested effects of vitamin D3 and omega-3s on change in BDNF; 3) explored modifying or mediating roles of BDNF on effects of vitamin D3 and omega-3s for LLD. We selected 400 adults from a completed trial of vitamin D3 and omega-3 supplements for LLD prevention. BDNF was measured using an enzyme-linked immunosorbent assay. We administered semi-structured diagnostic interviews and Patient Health Questionnaire [PHQ]-9 to ascertain outcomes at baseline (depression caseness vs. non-caseness; PHQ-9) and at 2-year follow-up among baseline non-depressed individuals (incident vs. no incident MDD; change in PHQ-9). At baseline, while there were no significant differences in mean serum BDNF comparing depression cases and non-cases, being in the lowest vs. highest serum BDNF quartile was significantly associated with worse depressive symptoms. There were no significant longitudinal associations between serum BDNF and LLD. Neither supplement significantly affected change in BDNF; serum BDNF did not appear to modify or mediate treatment effects on LLD. In conclusion, we observed significant cross-sectional but not longitudinal associations between serum BDNF levels and LLD. Vitamin D3 or omega-3s did not alter serum BDNF over 2 years.
Competing Interests: Declaration of competing interest Dr. Vyas has received research support from Nestlé-Purina Petcare Company and American Foundation for Suicide Prevention. Dr. Mischoulon has received research support from Nordic Naturals and Heckel Medizintechnik GmbH. He has received honoraria for speaking from the Massachusetts General Hospital Psychiatry Academy, Peerpoint Medical Education Institute, LLC, and Harvard blog. He also works with the MGH Clinical Trials Network and Institute (CTNI), which has received research funding from multiple pharmaceutical companies and NIMH. Dr. Chang receives royalties from Up-to-Date. Dr. Buring's spouse was on the Scientific Advisory Board of Pharmavite LLC during the trial. Dr. Mora has served as consultant to Pfizer and Quest Diagnostics. Dr. Manson has received research support from Mars Edge. Dr. Reynolds receives payment from the American Association of Geriatric Psychiatry as Editor-in-Chief of the American Journal of Geriatric Psychiatry, royalty income for intellectual property as co-inventor of the Pittsburgh Sleep Quality Index and, in the past, a one-time honorarium from Merck for consultation on care pathways for insomnia. Dr. Reynolds also receives royalty income from Oxford University Press and from Up-to-Date. Dr. Okereke receives royalties from Springer Publishing for a book on late-life depression prevention. No other authors have disclosures to report.
(Copyright © 2023. Published by Elsevier Ltd.)
Competing Interests: Declaration of competing interest Dr. Vyas has received research support from Nestlé-Purina Petcare Company and American Foundation for Suicide Prevention. Dr. Mischoulon has received research support from Nordic Naturals and Heckel Medizintechnik GmbH. He has received honoraria for speaking from the Massachusetts General Hospital Psychiatry Academy, Peerpoint Medical Education Institute, LLC, and Harvard blog. He also works with the MGH Clinical Trials Network and Institute (CTNI), which has received research funding from multiple pharmaceutical companies and NIMH. Dr. Chang receives royalties from Up-to-Date. Dr. Buring's spouse was on the Scientific Advisory Board of Pharmavite LLC during the trial. Dr. Mora has served as consultant to Pfizer and Quest Diagnostics. Dr. Manson has received research support from Mars Edge. Dr. Reynolds receives payment from the American Association of Geriatric Psychiatry as Editor-in-Chief of the American Journal of Geriatric Psychiatry, royalty income for intellectual property as co-inventor of the Pittsburgh Sleep Quality Index and, in the past, a one-time honorarium from Merck for consultation on care pathways for insomnia. Dr. Reynolds also receives royalty income from Oxford University Press and from Up-to-Date. Dr. Okereke receives royalties from Springer Publishing for a book on late-life depression prevention. No other authors have disclosures to report.
(Copyright © 2023. Published by Elsevier Ltd.)