학술논문
Urinary 1-hydroxypyrene in pregnant women in a Northeastern U.S. city: socioeconomic disparity and contributions from air pollution sources.
Document Type
Academic Journal
Author
Lin Y; Nicholas School of the Environment & Duke Global Health Institute, Duke University, Durham, NC, USA.; Craig E; Nicholas School of the Environment & Duke Global Health Institute, Duke University, Durham, NC, USA.; Liu X; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.; Ge Y; Nicholas School of the Environment & Duke Global Health Institute, Duke University, Durham, NC, USA.; Brunner J; Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, USA.; Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.; Wang X; Nicholas School of the Environment & Duke Global Health Institute, Duke University, Durham, NC, USA.; Yang Z; Nicholas School of the Environment & Duke Global Health Institute, Duke University, Durham, NC, USA.; Hopke PK; Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.; Institute for a Sustainable Environment, Clarkson University, Potsdam, NY, USA.; Miller RK; Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, USA.; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology and Clinical Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.; Barrett ES; Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, USA.; Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.; Department of Epidemiology and Biostatistics, Environmental and Occupational Health Sciences Institute, Rutgers School of Public Health, Piscataway, NJ, USA.; Thurston SW; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.; Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA.; Murphy SK; Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.; O'Connor TG; Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, USA.; Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.; Department of Psychology, University of Rochester, Rochester, NY, USA.; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.; Rich DQ; Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.; Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.; Zhang JJ; Nicholas School of the Environment & Duke Global Health Institute, Duke University, Durham, NC, USA. junfeng.zhang@duke.edu.
Source
Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101262796 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-064X (Electronic) Linking ISSN: 15590631 NLM ISO Abbreviation: J Expo Sci Environ Epidemiol Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Maternal exposure to polycyclic aromatic hydrocarbons (PAHs), ubiquitous constituents of air pollution, has been associated with adverse birth outcomes. Yet it remains unclear whether and how socioeconomic status (SES) affects gestational PAH exposure.
Objective: To examine whether there are socioeconomic disparities in PAHs exposure among pregnant women from Rochester, NY, and if so, to what extent disproportionate proximity to air pollution sources, measured by residential distance to transportation-related sources, contributed to the exposure disparity.
Methods: We measured 1-hydroxypyrene concentrations in 726 urine samples collected from 305 pregnant women up to three samples throughout pregnancy. Residential distances to transportation-related sources were calculated based on participants' home addresses. We used linear mixed-effects models with random intercepts of participants to examine associations between 1-hydroxypyrene, SES indicators, and distance to transportation-related sources. We used structural equation modelling to assess to what extent distance to transportation-related sources contributes to the socioeconomic disparity in 1-hydroxypyrene concentrations.
Results: Reduced household income and maternal education level were both significant SES predictors of 1-hydroxypyrene concentrations, after the adjustment for other maternal demographic characteristics. Each interquartile range (IQR) increases in residential proximity to the airport (from 14.3 to 6.0 km), the railroad yard (from 22.3 to 6.0 km), and annual average daily traffic within 300 m (from 3796 to 99,933 vehicles/year) were associated with 15.0% (95%CI: 7.0-22.2%), 15.4% (95%CI: 6.5-23.5%), and 13.6% (95%CI: 4.7-23.3%) increases in 1-hydroxypyrene concentrations, respectively. Proximity to these sources jointly explained 10% (95%CI: 1.6-18.4%) of the 1-hydroxypyrene concentration change associated with decreases in SES as a latent variable defined by both household income and education level.
Impact Statement: Our findings suggest that efforts to address disproportionate residential proximity to transportation-related sources may reduce the socioeconomic disparity in PAH exposure.
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Objective: To examine whether there are socioeconomic disparities in PAHs exposure among pregnant women from Rochester, NY, and if so, to what extent disproportionate proximity to air pollution sources, measured by residential distance to transportation-related sources, contributed to the exposure disparity.
Methods: We measured 1-hydroxypyrene concentrations in 726 urine samples collected from 305 pregnant women up to three samples throughout pregnancy. Residential distances to transportation-related sources were calculated based on participants' home addresses. We used linear mixed-effects models with random intercepts of participants to examine associations between 1-hydroxypyrene, SES indicators, and distance to transportation-related sources. We used structural equation modelling to assess to what extent distance to transportation-related sources contributes to the socioeconomic disparity in 1-hydroxypyrene concentrations.
Results: Reduced household income and maternal education level were both significant SES predictors of 1-hydroxypyrene concentrations, after the adjustment for other maternal demographic characteristics. Each interquartile range (IQR) increases in residential proximity to the airport (from 14.3 to 6.0 km), the railroad yard (from 22.3 to 6.0 km), and annual average daily traffic within 300 m (from 3796 to 99,933 vehicles/year) were associated with 15.0% (95%CI: 7.0-22.2%), 15.4% (95%CI: 6.5-23.5%), and 13.6% (95%CI: 4.7-23.3%) increases in 1-hydroxypyrene concentrations, respectively. Proximity to these sources jointly explained 10% (95%CI: 1.6-18.4%) of the 1-hydroxypyrene concentration change associated with decreases in SES as a latent variable defined by both household income and education level.
Impact Statement: Our findings suggest that efforts to address disproportionate residential proximity to transportation-related sources may reduce the socioeconomic disparity in PAH exposure.
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)