학술논문
The 24-year course of major depression in patients with borderline personality disorder and personality-disordered comparison subjects.
Document Type
Academic Journal
Author
Zanarini MC; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States. Electronic address: zanarini@mclean.harvard.edu.; Hörz-Sagstetter S; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States.; Temes CM; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States.; Frankenburg FR; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States.; Hein KE; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States.; Reich DB; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States.; Fitzmaurice GM; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States.
Source
Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
Subject
Language
English
Abstract
Background: This study had two main objectives. The first was to detail the prevalence of major depressive disorder over 24 years of follow-up for both patients with borderline personality disorder (BPD) and comparison subjects with other personality disorders (OPD). The second was to determine time-to-remission, recurrence, and new onset of major depression among these two groups of patients.
Methods: The SCID-I was administered to 290 borderline inpatients and 72 personality-disordered comparison subjects during their index admission. It was also re-administered at 12 contiguous two-year follow-up periods.
Results: The prevalence of major depression was significantly higher for borderline patients over time but declined significantly over time for those in both study groups. In terms of time to events, 93% of borderline patients meeting criteria for major depression at baseline experienced a two-year remission by the time of the 24-year follow-up. Recurrences were about as common (90% for those with remitted major depression). New onsets of major depression were also very common (86% for those without major depression during their index admission).
Limitations: Results may not pertain to less severely ill patients with BPD and those in less treatment.
Conclusions: Taken together, the results of this study suggest that the remitting-recurring course of major depression in borderline patients is very similar to the course of major depression in those with other types of personality disorder and those for whom major depression is their primary disorder.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Methods: The SCID-I was administered to 290 borderline inpatients and 72 personality-disordered comparison subjects during their index admission. It was also re-administered at 12 contiguous two-year follow-up periods.
Results: The prevalence of major depression was significantly higher for borderline patients over time but declined significantly over time for those in both study groups. In terms of time to events, 93% of borderline patients meeting criteria for major depression at baseline experienced a two-year remission by the time of the 24-year follow-up. Recurrences were about as common (90% for those with remitted major depression). New onsets of major depression were also very common (86% for those without major depression during their index admission).
Limitations: Results may not pertain to less severely ill patients with BPD and those in less treatment.
Conclusions: Taken together, the results of this study suggest that the remitting-recurring course of major depression in borderline patients is very similar to the course of major depression in those with other types of personality disorder and those for whom major depression is their primary disorder.
(Copyright © 2019 Elsevier B.V. All rights reserved.)