학술논문
Demographic, clinical and aetiological characteristics of patients with hepatocellular carcinoma followed between 2012 and 2017 at University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.
Document Type
Academic Journal
Author
Rakotozafindrabe ALR; Department of Gastroenterology, University Hospital Joseph Raseta Befelatanana, Antananarivo 101, Madagascar.; Razafindrazoto CI; Department of Gastroenterology, University Hospital Joseph Raseta Befelatanana, Antananarivo 101, Madagascar.; Laingonirina DHH; Department of Gastroenterology, University Hospital Joseph Raseta Befelatanana, Antananarivo 101, Madagascar.; Ralideramanambina TB; Department of Gastroenterology, University Hospital Joseph Raseta Befelatanana, Antananarivo 101, Madagascar.; Ralaizanaka BM; Department of Hepato-Gastroenterology, University Hospital Andrainjato, BP1487 Ambatoharanana, Fianarantsoa 301, Madagascar.; Maherison S; Department of Gastroenterology, University Hospital Joseph Raseta Befelatanana, Antananarivo 101, Madagascar.; Rakotomalala JA; Department of Hepato-Gastroenterology, University Hospital Mahavoky Atsimo, Mahajanga 401, Madagascar.; Randriamifidy NH; Department of Gastroenterology, University Hospital Joseph Raseta Befelatanana, Antananarivo 101, Madagascar.; Rasolonjatovo AS; Department of Gastroenterology, University Hospital Joseph Raseta Befelatanana, Antananarivo 101, Madagascar.; Rabenjanahary TH; Department of Gastroenterology, University Hospital Joseph Raseta Befelatanana, Antananarivo 101, Madagascar.; Razafimahefa SH; Department of Hepato-Gastroenterology, University Hospital Andrainjato, BP1487 Ambatoharanana, Fianarantsoa 301, Madagascar.; Ramanampamonjy RM; Department of Gastroenterology, University Hospital Joseph Raseta Befelatanana, Antananarivo 101, Madagascar.
Source
Publisher: ecancer Country of Publication: England NLM ID: 101392236 Publication Model: eCollection Cited Medium: Print ISSN: 1754-6605 (Print) Linking ISSN: 17546605 NLM ISO Abbreviation: Ecancermedicalscience Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
1754-6605
Abstract
Purpose: The aim of this study was to describe the demographic, clinical and aetiological characteristics of hepatocellular carcinoma (HCC) in a Malagasy population sample in view to defining an appropriate control program.
Methods: This was a retrospective, descriptive study conducted in the Gastroenterology Department, Joseph Raseta Befelatanana University Hospital, Antananarivo, over a period of 6 years (January 2012 to December 2017).
Results: A total of 42 patients were selected, 29 of whom were men (69.05%) and 13 women (30.95%) (sex ratio: 2.2). The mean age was 56.6 years with extremes of 21 and 82 years. Subjects aged 60-69 years were most affected (35.71%). Abdominal pain was the main revealing symptom (38.10%). The main aetiological factors were: hepatitis B virus (HBV) (42.86%), hepatitis C virus (19.05%) and chronic alcoholism (23.81%). All patients were cirrhotic, of which 23 patients (54.76%) had Child-Pugh B class and 15 (35.71%) Child-Pugh C. Twenty-six patients (61.90%) had α-foetoprotein level plus 500 ng/mL. Six patients (14.29%) had portal thrombosis at diagnosis. Twenty patients (47.62%) had advanced HCC (Barcelona Clinic Liver Cancer C (BCLC C)) and 21 (50%) had end-stage HCC (BCLC D). Management was palliative in 41/42 patients. The in-hospital death rate was 23.81%.
Conclusion: HCC are diagnosed at advanced stage in this study. The prognosis is poor for most patients. HBV infection is the main risk factor. An effort should be made for early diagnosis and prevention.
Competing Interests: No conflicts of interest to declare.
(© the authors; licensee ecancermedicalscience.)
Methods: This was a retrospective, descriptive study conducted in the Gastroenterology Department, Joseph Raseta Befelatanana University Hospital, Antananarivo, over a period of 6 years (January 2012 to December 2017).
Results: A total of 42 patients were selected, 29 of whom were men (69.05%) and 13 women (30.95%) (sex ratio: 2.2). The mean age was 56.6 years with extremes of 21 and 82 years. Subjects aged 60-69 years were most affected (35.71%). Abdominal pain was the main revealing symptom (38.10%). The main aetiological factors were: hepatitis B virus (HBV) (42.86%), hepatitis C virus (19.05%) and chronic alcoholism (23.81%). All patients were cirrhotic, of which 23 patients (54.76%) had Child-Pugh B class and 15 (35.71%) Child-Pugh C. Twenty-six patients (61.90%) had α-foetoprotein level plus 500 ng/mL. Six patients (14.29%) had portal thrombosis at diagnosis. Twenty patients (47.62%) had advanced HCC (Barcelona Clinic Liver Cancer C (BCLC C)) and 21 (50%) had end-stage HCC (BCLC D). Management was palliative in 41/42 patients. The in-hospital death rate was 23.81%.
Conclusion: HCC are diagnosed at advanced stage in this study. The prognosis is poor for most patients. HBV infection is the main risk factor. An effort should be made for early diagnosis and prevention.
Competing Interests: No conflicts of interest to declare.
(© the authors; licensee ecancermedicalscience.)