학술논문
The efficacy and safety of Nigella sativa in the management of osteoarthritis: A systematic review.
Document Type
Academic Journal
Author
Mousavi SE; Neurosciences Research Center, Aging Research Institute Tabriz University of Medical Sciences Tabriz Iran.; Noori M; Student Research Committee, School of Medicine Iran University of Medical Sciences Tehran Iran.; Marandi H; School of Medicine Urmia University of Medical Sciences Urmia Iran.; Fazlollahi A; Neurosciences Research Center, Aging Research Institute Tabriz University of Medical Sciences Tabriz Iran.; Nejadghaderi SA; HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health Kerman University of Medical Sciences Kerman Iran.; Research Center for Integrative Medicine in Aging, Aging Research Institute Tabriz University of Medical Sciences Tabriz Iran.; Rahmani S; Student Research Committee, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.; Noordoost M; Research Center for Integrative Medicine in Aging, Aging Research Institute Tabriz University of Medical Sciences Tabriz Iran.; Karamzad N; Department of Persian Medicine, School of Traditional Medicine Tabriz University of Medical Sciences Tabriz Iran.; Nutrition Research Center, Department of Biochemistry and Diet Therapy, School of Nutrition and Food Sciences Tabriz University of Medical Sciences Tabriz Iran.; Sullman MJM; Department of Life and Health Sciences University of Nicosia Nicosia Cyprus.; Department of Social Sciences University of Nicosia Nicosia Cyprus.; Kolahi AA; Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran.; Safiri S; Neurosciences Research Center, Aging Research Institute Tabriz University of Medical Sciences Tabriz Iran.; Clinical Research Development Unit of Tabriz Valiasr Hospital Tabriz University of Medical Sciences Tabriz Iran.
Source
Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 101728855 Publication Model: eCollection Cited Medium: Internet ISSN: 2398-8835 (Electronic) Linking ISSN: 23988835 NLM ISO Abbreviation: Health Sci Rep Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Background and Aims: Osteoarthritis (OA) is one of the most common debilitating diseases among the aging population. Nigella sativa is one potential treatment for OA. Here, we sought to evaluate the efficacy and safety of Nigella sativa for treating patients with OA.
Methods: PubMed, Scopus, Embase, and Web of Science were searched up to October 20, 2022. The primary outcome was changes in the pain score after receiving Nigella sativa or control agents based on the results of randomized controlled trials (RCTs). The secondary outcome was set as the frequency of adverse events reported during the follow-up period.
Results: Six RCTs involving a total of 370 patients with knee OA were included in the present systematic review. Among the four screened studies, the topical administration of Nigella sativa oil was found to be more effective than the placebo in relieving pain in three trials. Additionally, the oral use of Nigella sativa oil was assessed in two trials, and an improvement in pain score relative to placebo was documented in only one of the studies. Also, the trial that evaluated the effectiveness of Nigella sativa oral capsules did not demonstrate any difference in pain reduction between the intervention and placebo groups. Overall, either topical or oral administration of Nigella sativa was well tolerated, and no serious adverse events were reported.
Conclusion: Nigella sativa is generally safe, but conflicting findings from low-quality studies hinder the ability to make clinical recommendations for or against treating OA. Robust trials are needed for informed decisions.
Competing Interests: The authors declare no conflicts of interest.
(© 2024 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Methods: PubMed, Scopus, Embase, and Web of Science were searched up to October 20, 2022. The primary outcome was changes in the pain score after receiving Nigella sativa or control agents based on the results of randomized controlled trials (RCTs). The secondary outcome was set as the frequency of adverse events reported during the follow-up period.
Results: Six RCTs involving a total of 370 patients with knee OA were included in the present systematic review. Among the four screened studies, the topical administration of Nigella sativa oil was found to be more effective than the placebo in relieving pain in three trials. Additionally, the oral use of Nigella sativa oil was assessed in two trials, and an improvement in pain score relative to placebo was documented in only one of the studies. Also, the trial that evaluated the effectiveness of Nigella sativa oral capsules did not demonstrate any difference in pain reduction between the intervention and placebo groups. Overall, either topical or oral administration of Nigella sativa was well tolerated, and no serious adverse events were reported.
Conclusion: Nigella sativa is generally safe, but conflicting findings from low-quality studies hinder the ability to make clinical recommendations for or against treating OA. Robust trials are needed for informed decisions.
Competing Interests: The authors declare no conflicts of interest.
(© 2024 The Authors. Health Science Reports published by Wiley Periodicals LLC.)