학술논문
Willingness to Self-Collect a Sample for HPV-Based Cervical Cancer Screening in a Well-Screened Cohort: HPV FOCAL Survey Results.
Document Type
Academic Journal
Author
Lesack A; Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Smith LW; Cancer Control Research, BC Cancer, Vancouver, BC V5Z 1L3, Canada.; Women's Health Research Institute, BC Women's Hospital, Vancouver, BC V6H 3N1, Canada.; Racey CS; Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Women's Health Research Institute, BC Women's Hospital, Vancouver, BC V6H 3N1, Canada.; Gondara L; Cancer Surveillance and Outcomes, BC Cancer, Vancouver, BC V5Z 4E6, Canada.; Krajden M; Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Public Health Laboratory, BC Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada.; Lee M; Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Cervix Screening Program, BC Cancer, Vancouver, BC V5Z 4E6, Canada.; Martin RE; Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Stuart G; Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Peacock S; Cancer Control Research, BC Cancer, Vancouver, BC V5Z 1L3, Canada.; Faculty of Health Sciences, Simon Fraser University, Vancouver, BC V5A 1S6, Canada.; Franco EL; Division of Cancer Epidemiology, Faculty of Medicine, McGill University, Montreal, QC H4A 3T2, Canada.; van Niekerk D; Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Cervix Screening Program, BC Cancer, Vancouver, BC V5Z 4E6, Canada.; Ogilvie GS; Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Women's Health Research Institute, BC Women's Hospital, Vancouver, BC V6H 3N1, Canada.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 9502503 Publication Model: Electronic Cited Medium: Internet ISSN: 1718-7729 (Electronic) Linking ISSN: 11980052 NLM ISO Abbreviation: Curr Oncol Subsets: MEDLINE
Subject
Language
English
Abstract
Self-collection may provide an opportunity for innovation within population-based human papillomavirus (HPV) cervical cancer screening programs by providing an alternative form of engagement for all individuals. The primary objective was to determine willingness to self-collect a vaginal sample for primary HPV screening and factors that impact willingness in individuals who participated in the Human Papillomavirus For Cervical Cancer (HPV FOCAL) screening trial, a large randomized controlled cervical screening trial. A cross-sectional online survey was distributed between 2017 and 2018 to 13,176 eligible participants exiting the FOCAL trial. Bivariate and multivariable logistic regression assessed factors that influence willingness to self-collect on 4945 respondents. Overall, 52.1% of respondents indicated willingness to self-collect an HPV sample. In multivariable analysis, the odds of willingness to self-collect were significantly higher in participants who agreed that screening with an HPV test instead of a Pap test was acceptable to them (odds ratio (OR): 1.45 (95% confidence interval (CI): 1.15, 1.82), those who indicated that collecting their own HPV sample was acceptable to them (p < 0.001), and those with higher educational ascertainment (OR: 1.31, 95% CI: 1.12, 1.54). The findings offer insight into the intentions to self-collect in those already engaged in screening, and can inform cervical cancer screening programs interested in offering alternative approaches to HPV-based screening.