학술논문
TMS Correlates of Pyramidal Tract Signs and Clinical Motor Status in Patients with Cervical Spondylotic Myelopathy.
Document Type
Academic Journal
Author
Lanza G; Department of Surgery and Medical-Surgical Specialties, University of Catania, Via Santa Sofia, 78-95123 Catania, Italy.; Department of Neurology IC, Oasi Research Institute-IRCCS, Via Conte Ruggero, 73-94018 Troina, Italy.; Puglisi V; Department of Neurology and Stroke Unit, ASST Cremona, Viale Concordia, 1-26100 Cremona, Italy.; Vinciguerra L; Department of Neurology and Stroke Unit, ASST Cremona, Viale Concordia, 1-26100 Cremona, Italy.; Fisicaro F; Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia, 89-95123 Catania, Italy.; Vagli C; Department of Neurology, San Giovanni di Dio Hospital, ASP Agrigento, Contrada Consolida, 92100 Agrigento, Italy.; Cantone M; Department of Neurology, Sant'Elia Hospital, ASP Caltanissetta, Via Luigi Russo, 6-93100 Caltanissetta, Italy.; Pennisi G; Department of Surgery and Medical-Surgical Specialties, University of Catania, Via Santa Sofia, 78-95123 Catania, Italy.; Pennisi M; Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia, 89-95123 Catania, Italy.; Bella R; Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, Via Santa Sofia, 78-95123 Catania, Italy.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101598646 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3425 (Print) Linking ISSN: 20763425 NLM ISO Abbreviation: Brain Sci Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2076-3425
Abstract
Background: While the association between motor-evoked potential (MEP) abnormalities and motor deficit is well established, few studies have reported the correlation between MEPs and signs of pyramidal tract dysfunction without motor weakness. We assessed MEPs in patients with pyramidal signs, including motor deficits, compared to patients with pyramidal signs but without weakness.
Methods: Forty-three patients with cervical spondylotic myelopathy (CSM) were dichotomized into 21 with pyramidal signs including motor deficit (Group 1) and 22 with pyramidal signs and normal strength (Group 2), and both groups were compared to 33 healthy controls (Group 0). MEPs were bilaterally recorded from the first dorsal interosseous and tibialis anterior muscle. The central motor conduction time (CMCT) was estimated as the difference between MEP latency and peripheral latency by magnetic stimulation. Peak-to-peak MEP amplitude and right-to-left differences were also measured.
Results: Participants were age-, sex-, and height-matched. MEP latency in four limbs and CMCT in the lower limbs were prolonged, and MEP amplitude in the lower limbs decreased in Group 1 compared to the others. Unlike motor deficit, pyramidal signs were not associated with MEP measures, even when considering age, sex, and height as confounding factors.
Conclusions: In CSM, isolated pyramidal signs may not be associated, at this stage, with MEP changes.
Methods: Forty-three patients with cervical spondylotic myelopathy (CSM) were dichotomized into 21 with pyramidal signs including motor deficit (Group 1) and 22 with pyramidal signs and normal strength (Group 2), and both groups were compared to 33 healthy controls (Group 0). MEPs were bilaterally recorded from the first dorsal interosseous and tibialis anterior muscle. The central motor conduction time (CMCT) was estimated as the difference between MEP latency and peripheral latency by magnetic stimulation. Peak-to-peak MEP amplitude and right-to-left differences were also measured.
Results: Participants were age-, sex-, and height-matched. MEP latency in four limbs and CMCT in the lower limbs were prolonged, and MEP amplitude in the lower limbs decreased in Group 1 compared to the others. Unlike motor deficit, pyramidal signs were not associated with MEP measures, even when considering age, sex, and height as confounding factors.
Conclusions: In CSM, isolated pyramidal signs may not be associated, at this stage, with MEP changes.