학술논문
Quantitative susceptibility mapping demonstrates different patterns of iron overload in subtypes of early-onset Alzheimer's disease.
Document Type
Academic Journal
Author
Kuchcinski G; Inserm, U1172 - LilNCog - Lille Neuroscience & Cognition, Univ Lille, F-59000, Lille, France. gregory.kuchcinski@univ-lille.fr.; UMS 2014 - US 41 - PLBS - Plateformes Lilloises en Biologie & Santé, Univ Lille, F-59000, Lille, France. gregory.kuchcinski@univ-lille.fr.; Department of Neuroradiology, CHU Lille, Rue Emile Laine, F-59000, Lille, France. gregory.kuchcinski@univ-lille.fr.; Patin L; Department of Neuroradiology, CHU Lille, Rue Emile Laine, F-59000, Lille, France.; Lopes R; Inserm, U1172 - LilNCog - Lille Neuroscience & Cognition, Univ Lille, F-59000, Lille, France.; UMS 2014 - US 41 - PLBS - Plateformes Lilloises en Biologie & Santé, Univ Lille, F-59000, Lille, France.; Leroy M; Memory Center - CNR MAJ, DISTALZ-LICEND, F-59000, Lille, France.; Delbeuck X; Memory Center - CNR MAJ, DISTALZ-LICEND, F-59000, Lille, France.; Rollin-Sillaire A; Memory Center - CNR MAJ, DISTALZ-LICEND, F-59000, Lille, France.; Department of Neurology, CHU Lille, F-59000, Lille, France.; Lebouvier T; Inserm, U1172 - LilNCog - Lille Neuroscience & Cognition, Univ Lille, F-59000, Lille, France.; Memory Center - CNR MAJ, DISTALZ-LICEND, F-59000, Lille, France.; Department of Neurology, CHU Lille, F-59000, Lille, France.; Wang Y; Department of Radiology, Weill Cornell Medical College, New York, NY, USA.; Spincemaille P; Department of Radiology, Weill Cornell Medical College, New York, NY, USA.; Tourdias T; Neuroimagerie diagnostique et thérapeutique, CHU de Bordeaux, F-33000, Bordeaux, France.; Neurocentre Magendie, Inserm, U1215, Université de Bordeaux, F-33000, Bordeaux, France.; Hacein-Bey L; Radiology Department, University of California Davis School of Medicine, Sacramento, CA, USA.; Devos D; Inserm, U1172 - LilNCog - Lille Neuroscience & Cognition, Univ Lille, F-59000, Lille, France.; Department of Pharmacology, CHU Lille, F-59000, Lille, France.; Pasquier F; Inserm, U1172 - LilNCog - Lille Neuroscience & Cognition, Univ Lille, F-59000, Lille, France.; Memory Center - CNR MAJ, DISTALZ-LICEND, F-59000, Lille, France.; Department of Neurology, CHU Lille, F-59000, Lille, France.; Leclerc X; Inserm, U1172 - LilNCog - Lille Neuroscience & Cognition, Univ Lille, F-59000, Lille, France.; UMS 2014 - US 41 - PLBS - Plateformes Lilloises en Biologie & Santé, Univ Lille, F-59000, Lille, France.; Department of Neuroradiology, CHU Lille, Rue Emile Laine, F-59000, Lille, France.; Pruvo JP; Inserm, U1172 - LilNCog - Lille Neuroscience & Cognition, Univ Lille, F-59000, Lille, France.; UMS 2014 - US 41 - PLBS - Plateformes Lilloises en Biologie & Santé, Univ Lille, F-59000, Lille, France.; Department of Neuroradiology, CHU Lille, Rue Emile Laine, F-59000, Lille, France.; Verclytte S; Department of Imaging, Lille Catholic Hospitals, Lille Catholic University, F-59000, Lille, France.
Source
Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE
Subject
Language
English
Abstract
Objectives: We aimed to define brain iron distribution patterns in subtypes of early-onset Alzheimer's disease (EOAD) by the use of quantitative susceptibility mapping (QSM).
Methods: EOAD patients prospectively underwent MRI on a 3-T scanner and concomitant clinical and neuropsychological evaluation, between 2016 and 2019. An age-matched control group was constituted of cognitively healthy participants at risk of developing AD. Volumetry of the hippocampus and cerebral cortex was performed on 3DT1 images. EOAD subtypes were defined according to the hippocampal to cortical volume ratio (HV:CTV). Limbic-predominant atrophy (LPMRI ) is referred to HV:CTV ratios below the 25 th percentile, hippocampal-sparing (HpSp MRI ) above the 75 th percentile, and typical-AD between the 25 th and 75 th percentile. Brain iron was estimated using QSM. QSM analyses were made voxel-wise and in 7 regions of interest within deep gray nuclei and limbic structures. Iron distribution in EOAD subtypes and controls was compared using an ANOVA.
Results: Sixty-eight EOAD patients and 43 controls were evaluated. QSM values were significantly higher in deep gray nuclei (p < 0.001) and limbic structures (p = 0.04) of EOAD patients compared to controls. Among EOAD subtypes, HpSpMRI had the highest QSM values in deep gray nuclei (p < 0.001) whereas the highest QSM values in limbic structures were observed in LP MRI (p = 0.005). QSM in deep gray nuclei had an AUC = 0.92 in discriminating HpSp MRI and controls.
Conclusions: In early-onset Alzheimer's disease patients, we observed significant variations of iron distribution reflecting the pattern of brain atrophy. Iron overload in deep gray nuclei could help to identify patients with atypical presentation of Alzheimer's disease.
Key Points: • In early-onset AD patients, QSM indicated a significant brain iron overload in comparison with age-matched controls. • Iron load in limbic structures was higher in participants with limbic-predominant subtype. • Iron load in deep nuclei was more important in participants with hippocampal-sparing subtype.
(© 2022. The Author(s), under exclusive licence to European Society of Radiology.)
Methods: EOAD patients prospectively underwent MRI on a 3-T scanner and concomitant clinical and neuropsychological evaluation, between 2016 and 2019. An age-matched control group was constituted of cognitively healthy participants at risk of developing AD. Volumetry of the hippocampus and cerebral cortex was performed on 3DT1 images. EOAD subtypes were defined according to the hippocampal to cortical volume ratio (HV:CTV). Limbic-predominant atrophy (LP
Results: Sixty-eight EOAD patients and 43 controls were evaluated. QSM values were significantly higher in deep gray nuclei (p < 0.001) and limbic structures (p = 0.04) of EOAD patients compared to controls. Among EOAD subtypes, HpSp
Conclusions: In early-onset Alzheimer's disease patients, we observed significant variations of iron distribution reflecting the pattern of brain atrophy. Iron overload in deep gray nuclei could help to identify patients with atypical presentation of Alzheimer's disease.
Key Points: • In early-onset AD patients, QSM indicated a significant brain iron overload in comparison with age-matched controls. • Iron load in limbic structures was higher in participants with limbic-predominant subtype. • Iron load in deep nuclei was more important in participants with hippocampal-sparing subtype.
(© 2022. The Author(s), under exclusive licence to European Society of Radiology.)