학술논문
Serotonin 5-HT1A receptor binding in people with panic disorder: positron emission tomography study.
Document Type
Academic Journal
Author
Nash JR; University of Bristol, Bristol BS1 3NY, UK.; Sargent PA; Rabiner EA; Hood SD; Argyropoulos SV; Potokar JP; Grasby PM; Nutt DJ
Source
Publisher: Cambridge University Press Country of Publication: England NLM ID: 0342367 Publication Model: Print Cited Medium: Print ISSN: 0007-1250 (Print) Linking ISSN: 00071250 NLM ISO Abbreviation: Br J Psychiatry Subsets: MEDLINE
Subject
Language
English
ISSN
0007-1250
Abstract
Background: The importance of the neurotransmitter serotonin (5-HT) in the pathophysiology of anxiety is well known. A key role for postsynaptic 5-HT(1A) receptors has recently been suggested in studies of genetic knockout mice.
Aims: To measure 5-HT(1A) receptor binding in patients with panic disorder in the untreated state and after recovery on treatment with selective serotonin reuptake inhibitors (SSRIs).
Method: Nine symptomatic untreated patients with panic disorder, seven patients recovered on SSRI medication and nineteen healthy volunteers underwent a single positron emission tomography (PET) scan using the 5-HT(1A) tracer [(11)C]WAY-100635.
Results: In comparison with controls, both presynaptic and postsynaptic 5-HT(1A) receptor binding was reduced in untreated patients, with the most significant reductions being in the raphe, orbitofrontal cortex, temporal cortex and amygdala. In recovered patients presynaptic binding was reduced, but there was no significant reduction in postsynaptic binding.
Conclusions: Panic disorder is associated with reduced 5-HT(1A) receptor availability, which is also known to have a key role in depression.
Aims: To measure 5-HT(1A) receptor binding in patients with panic disorder in the untreated state and after recovery on treatment with selective serotonin reuptake inhibitors (SSRIs).
Method: Nine symptomatic untreated patients with panic disorder, seven patients recovered on SSRI medication and nineteen healthy volunteers underwent a single positron emission tomography (PET) scan using the 5-HT(1A) tracer [(11)C]WAY-100635.
Results: In comparison with controls, both presynaptic and postsynaptic 5-HT(1A) receptor binding was reduced in untreated patients, with the most significant reductions being in the raphe, orbitofrontal cortex, temporal cortex and amygdala. In recovered patients presynaptic binding was reduced, but there was no significant reduction in postsynaptic binding.
Conclusions: Panic disorder is associated with reduced 5-HT(1A) receptor availability, which is also known to have a key role in depression.