학술논문
Cognition and post-concussive symptom status after pediatric mild traumatic brain injury.
Document Type
Academic Journal
Author
Robertson-Benta CR; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.; Pabbathi Reddy S; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.; Stephenson DD; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.; Sicard V; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.; Hergert DC; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.; Dodd AB; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.; Campbell RA; Department of Psychiatry and Behavioral Sciences, University of New Mexico, Albuquerque, NM, USA.; Phillips JP; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.; Departments of Psychology and Neurology, University of New Mexico, Albuquerque, NM, USA.; Meier TB; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.; Quinn DK; Department of Psychiatry and Behavioral Sciences, University of New Mexico, Albuquerque, NM, USA.; Mayer AR; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.; Department of Psychiatry and Behavioral Sciences, University of New Mexico, Albuquerque, NM, USA.; Departments of Psychology and Neurology, University of New Mexico, Albuquerque, NM, USA.
Source
Publisher: Routledge Country of Publication: England NLM ID: 9512515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4136 (Electronic) Linking ISSN: 09297049 NLM ISO Abbreviation: Child Neuropsychol Subsets: MEDLINE
Subject
Language
English
Abstract
Cognitive impairment and post-concussive symptoms (PCS) represent hallmark sequelae of pediatric mild traumatic brain injury (pmTBI). Few studies have directly compared cognition as a function of PCS status longitudinally. Cognitive outcomes were therefore compared for asymptomatic pmTBI, symptomatic pmTBI, and healthy controls (HC) during sub-acute (SA; 1-11 days) and early chronic (EC; approximately 4 months) post-injury phases. We predicted worse cognitive performance for both pmTBI groups relative to HC at the SA visit. At the EC visit, we predicted continued impairment from the symptomatic group, but no difference between asymptomatic pmTBI and HCs. A battery of clinical (semi-structured interviews and self-report questionnaires) and neuropsychological measures were administered to 203 pmTBI and 139 HC participants, with greater than 80% retention at the EC visit. A standardized change method classified pmTBI into binary categories of asymptomatic or symptomatic based on PCS scores. Symptomatic pmTBI performed significantly worse than HCs on processing speed, attention, and verbal memory at SA visit, whereas lower performance was only present for verbal memory for asymptomatic pmTBI. Lower performance in verbal memory persisted for both pmTBI groups at the EC visit. Surprisingly, a minority (16%) of pmTBI switched from asymptomatic to symptomatic status at the EC visit. Current findings suggest that PCS and cognition are more closely coupled during the first week of injury but become decoupled several months post-injury. Evidence of lower performance in verbal memory for both asymptomatic and symptomatic pmTBI suggests that cognitive recovery may be a process separate from the resolution of subjective symptomology.